Table 4 Experimental designs and the results of Box-Behnken design for optimizing reaction conditions for the production of D- isoascorbyl palmitate

1

1(20)

−1(40)

0(4)

92.70

93.86

93.28 ± 0.82

90.33

2

0(13)

1(60)

1(6)

84.78

85.74

85.26 ± 0.68

80.98

3

−1(5)

1(60)

0(4)

62.69

64.63

63.66 ± 1.37

66.61

4

−1(5)

0(50)

1(2)

65.89

66.25

66.07 ± 0.25

67.40

5

0(13)

0(50)

0(4)

84.03

84.75

84.39 ± 0.51

84.66

6

1(20)

0(50)

−1(2)

86.89

85.53

86.21 ± 0.96

84.88

7

1(20)

0(50)

1(6)

85.78

87.46

86.62 ± 1.19

86.91

8

0(13)

−1(40)

−1(2)

50.00

50.60

50.30 ± 0.42

54.58

9

0(13)

1(60)

−1(2)

70.98

71.38

71.18 ± 0.28

68.53

10

−1(5)

0(50)

−1(2)

37.08

37.06

37.07 ± 0.01

36.78

11

0(13)

−1(40)

1(6)

72.88

71.36

72.12 ± 1.07

74.78

12

−1(5)

−1(40)

0(4)

53.89

55.75

54.82 ± 1.32

50.83

13

1(20)

1(60)

0(4)

90.22

91.24

90.73 ± 0.72

94.72

14

0(13)

0(50)

0(4)

83.97

86.01

84.99 ± 1.44

84.66

15

0(13)

0(50)

0(4)

85.02

84.20

84.61 ± 0.58

84.66