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Table 4 Experimental designs and the results of Box-Behnken design for optimizing reaction conditions for the production of D- isoascorbyl palmitate

From: D-isoascorbyl palmitate: lipase-catalyzed synthesis, structural characterization and process optimization using response surface methodology

Runs Coded levels Conversion rate (%)
A B C I II Average Predicted
1 1(20) −1(40) 0(4) 92.70 93.86 93.28 ± 0.82 90.33
2 0(13) 1(60) 1(6) 84.78 85.74 85.26 ± 0.68 80.98
3 −1(5) 1(60) 0(4) 62.69 64.63 63.66 ± 1.37 66.61
4 −1(5) 0(50) 1(2) 65.89 66.25 66.07 ± 0.25 67.40
5 0(13) 0(50) 0(4) 84.03 84.75 84.39 ± 0.51 84.66
6 1(20) 0(50) −1(2) 86.89 85.53 86.21 ± 0.96 84.88
7 1(20) 0(50) 1(6) 85.78 87.46 86.62 ± 1.19 86.91
8 0(13) −1(40) −1(2) 50.00 50.60 50.30 ± 0.42 54.58
9 0(13) 1(60) −1(2) 70.98 71.38 71.18 ± 0.28 68.53
10 −1(5) 0(50) −1(2) 37.08 37.06 37.07 ± 0.01 36.78
11 0(13) −1(40) 1(6) 72.88 71.36 72.12 ± 1.07 74.78
12 −1(5) −1(40) 0(4) 53.89 55.75 54.82 ± 1.32 50.83
13 1(20) 1(60) 0(4) 90.22 91.24 90.73 ± 0.72 94.72
14 0(13) 0(50) 0(4) 83.97 86.01 84.99 ± 1.44 84.66
15 0(13) 0(50) 0(4) 85.02 84.20 84.61 ± 0.58 84.66