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Table 1 Results of various biological assays on compounds 39

From: Synthesis, reactions and biological activity of some new bis-heterocyclic ring compounds containing sulphur atom

Compounds IC50 ± SEM [μM]
  Anticancer activity (PC-3 cell line) DPPH radical scavenging assay ß-Glucuronidase inhibition α-Glucosidase inhibition
3 >30 56.26 ± 3.18 NA NA
4a >30 NA - -
4b >30 NA NA NA
5a >30 NA 0.130 ± 0.019 -
5b >30 NA 19.9 ± 0.285 -
6 >30 NA 1.2 ± 0.0785 -
7 >30 NA NA -
8a >30 - 1.2 ± 0.0785 13.2 ± 0.34
8b 24.213 ± 0.29 - NA 14.1 ± 0.28
9a >30 NA 0.003 ± 0.09 NA
9b >30 NA NA -
Std. Doxorubicin 0.91 ± 0.1 N-Acetylcysteine 106 ± 1.1 D-Saccharic acid 1,4- lactone 45.75 ± 2.16 Acarbose 841 ± 1.7
  1. SEM = standard error of mean.
  2. NA = not active; failed to show 50% or more inhibition at 500 μM or more.