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Table 1 Inhibitory effect of compounds 1–10 on human AChE and BChE

From: Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of humanacetylcholinesterase and butyrylcholinesterase

Lycorine analogue No. IC50(μM)  
hAChE hBChE
1,2-O,O'-Dibenzoyllycorine 1 > 50 7.72 ± 0.26
2-O-Benzoyllycorine 2 > 50 > 50
1,2-O,O'-Di-trans-cinnamoyllycorine 3 46.76 ± 0.95 17.45 ± 0.19
2-O-trans-Cinnamoyllycorine 4 > 50 19.74 ± 1.37
1-O-trans-Cinnamoyllycorine 5 > 50 12.13 ± 0.77
1-O-Acetyl-2-O-tert-butyldimethylsilyllycorine 6 > 50 > 50
2-O-tert-Butyldimethylsilyl-1-O-(methylthio)methyllycorine 7 11.40 ± 0.66 4.17 ± 0.29
Lycorin-2-one 8 > 50 > 50
1-O-Acetyllycorin-2-one 9 > 50 44.46 ± 0.88
1-O-trans-Cinnamoyllycorin-2-one 10 > 50 20.91 ± 0.13
Tacrine (positive control)   0.26 ± 0.015 0.02 ± 0.00
Galanthamine (positive control)   1.60 ± 0.14 18.30 ± 0.14