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Table 3 Summary of stress degradation studies of chloramphenicol (2).

From: Stress degradation studies and development of stability-indicating TLC-densitometry method for determination of prednisolone acetate and chloramphenicol in their individual and combined pharmaceutical formulations

Degradation conditions % Degradation Rf of degraded products
Acidic hydrolysisa   
1N HCl 23.75 0.01, 0.04
5N HCl 69.36 0.01, 0.04, 0.81
Basic hydrolysisa   
0.1N NaOH 100 0.01, 0.44, 0.79
1N NaOH 100 0.01, 0.04, 0.81
5N NaOH 100 0.01, 0.02, 0.04, 0.48
Neutral hydrolysisa   
H2O 14.35 0.01
Wet heatinga 28.44 0.01, 0.79
Dry heating 24 0.01, 0.79
Photochemical 26.029 0.01,0.09,0.15, 0.27,0.44,0.81,0.85
Oxidation   
35%v/v H2O2 a 4.129 0.01, 0.12, 0.31
Oxidation at room temp 9.58 0.01, 0.12, 0.31
  1. aReflux in parallel synthesizer for two hours at 80°C