Skip to main content

Table 1 Antiproliferative evaluation results of the synthesized combinatorial mixtures M1-M22 and schematic representation of an orthogonal deconvolution for prediction of the active compounds

From: Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity

Hydrazides A B C D E F G H I J K   
Isatins Set 1 IC50a (μM)
1 A1 B1 C1 D1 E1 F1 G1 H1 I1 J1 K1 M1 7.1 ± 0.04
2 A2 B2 C2 D2 E2 F2 G2 H2 I2 J2 K2 M2 9.76 ± 0.027
3 A3 B3 C3 D3 E3 F3 G3 H3 I3 J3 K3 M3 7.16 ± 0.069
4 A4 B4 C4 D4 E4 F4 G4 H4 I4 J4 K4 M4 6.63 ± 0.02
5 A5 B5 C5 D5 E5 F5 G5 H5 I5 J5 K5 M5 4.53 ± 0.028
6 A6 B6 C6 D6 E6 F6 G6 H6 I6 J6 K6 M6 4.48 ± 0.015
7 A7 B7 C7 D7 E7 F7 G7 H7 I7 J7 K7 M7 5.09 ± 0.01
8 A8 B8 C8 D8 E8 F8 G8 H8 I8 J8 K8 M8 b
9 A9 B9 C9 D9 E9 F9 G9 H9 I9 J9 K9 M9 9.29 ± 0.019
10 A10 B10 C10 D10 E10 F10 G10 H10 I10 J10 K10 M10 9.76 ± 0.018
11 A11 B11 C11 D11 E11 F11 G11 H11 I11 J11 K11 M11 14.57 ± 0.05
Set 2 M12 M13 M14 M15 M16 M17 M18 M19 M20 M21 M22   
IC50a (μM) 12.02±0.026 b 22.6±0.038 4.85±0.018 10.1±0.05 b 9.64±0.003 21.06±0.02 b b 4.51±0.003   
  1. aIC50: concentration of the compound (μM) producing 50 % cell growth inhibition after 48 h of compound exposure, as determined by the WST-1 assay. Each experiment was run at least two times, and the results are presented as average values±standard deviation. bCompounds or mixtures having IC50 value > 100 μM.