Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity

BMC Chemistry

Table 1 Antiproliferative evaluation results of the synthesized combinatorial mixtures M1-M22 and schematic representation of an orthogonal deconvolution for prediction of the active compounds

Hydrazides	A	B	C	D	E	F	G	H	I	J	K
Isatins												Set 1	IC₅₀^a (μM)
1	A1	B1	C1	D1	E1	F1	G1	H1	I1	J1	K1	M1	7.1 ± 0.04
2	A2	B2	C2	D2	E2	F2	G2	H2	I2	J2	K2	M2	9.76 ± 0.027
3	A3	B3	C3	D3	E3	F3	G3	H3	I3	J3	K3	M3	7.16 ± 0.069
4	A4	B4	C4	D4	E4	F4	G4	H4	I4	J4	K4	M4	6.63 ± 0.02
5	A5	B5	C5	D5	E5	F5	G5	H5	I5	J5	K5	M5	4.53 ± 0.028
6	A6	B6	C6	D6	E6	F6	G6	H6	I6	J6	K6	M6	4.48 ± 0.015
7	A7	B7	C7	D7	E7	F7	G7	H7	I7	J7	K7	M7	5.09 ± 0.01
8	A8	B8	C8	D8	E8	F8	G8	H8	I8	J8	K8	M8	^b
9	A9	B9	C9	D9	E9	F9	G9	H9	I9	J9	K9	M9	9.29 ± 0.019
10	A10	B10	C10	D10	E10	F10	G10	H10	I10	J10	K10	M10	9.76 ± 0.018
11	A11	B11	C11	D11	E11	F11	G11	H11	I11	J11	K11	M11	14.57 ± 0.05
Set 2	M12	M13	M14	M15	M16	M17	M18	M19	M20	M21	M22
IC₅₀^a (μM)	12.02±0.026	^b	22.6±0.038	4.85±0.018	10.1±0.05	^b	9.64±0.003	21.06±0.02	^b	^b	4.51±0.003

^aIC₅₀: concentration of the compound (μM) producing 50 % cell growth inhibition after 48 h of compound exposure, as determined by the WST-1 assay. Each experiment was run at least two times, and the results are presented as average values±standard deviation. ^bCompounds or mixtures having IC₅₀ value > 100 μM.

ISSN: 2661-801X