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Table 4 IC 50 for DPPH and ABTS radical scavenging ability of hydrazinyl thiazolyl coumarins 10 and comparison with known antioxidants BHT and quercetin

From: Microwave-assisted synthesis and antioxidant properties of hydrazinyl thiazolyl coumarin derivatives

Entry

Compound

R1

R2

R3

R4

DPPH assay IC50/μM†

ABTS assay IC50/μM‡

1

10a

OH

H

H

H

26 ± 0.96

32 ± 3.06

2

10b

H

OH

H

H

47 ± 1.24

53 ± 2.74

3

10c

H

H

OH

H

28 ± 0.62

41 ± 3.95

4

10d

OH

H

OH

H

24 ± 0.67

29 ± 1.88

5

10e

OH

H

H

Br

16 ± 0.82

19 ± 2.76

6

10f

OH

OMe

H

H

30 ± 0.78

36 ± 3.18

7

10g

H

-

-

-

85 ± 0.66

78 ± 5.64

8

10h

OH

-

-

-

22 ± 1.75

32 ± 3.42

9

BHT

-

-

-

-

71 ± 0.82

-

10

quercetin

-

-

-

-

18 ± 0.99

20 ± 2.19

11

Trolox

-

-

-

-

-

112 ± 4.29

  1. † Required concentration of the tested compound to scavenge 50% of the DPPH radical present at a concentration of 0.1 mM; average from 3 assays. ‡ Required concentration of the tested compound to scavenge 50% of the ABTS radical present at a concentration of 0.12 mM; average from 3 assays.
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BMC Chemistry

ISSN: 2661-801X

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