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Table 1 Thermodynamic parameters of RNA/DNA duplexes 1/2, 1/7, and 1/8.a, b

From: Cleavage of pyrene-stabilized RNA bulge loops by trans-(±)-cyclohexane-1,2-diamine

Duplex

ΔH (kcal/mol)

ΔS (cal/mol·K)

Tm (°C)c

ΔG298 (kcal/mol)

1/2

-214.7

-607

68.8 ± 0.3

-33.8

1/7

-126.0

-365

55.7 ± 0.4

-17.2

1/8

-83.5

-238

48.5 ± 0.3

-12.6

  1. a. RNA is not labeled with FAM.
  2. b. Buffer: 10 mM PIPES (pH 7.5), 100 mM NaCl, 1 mM Tris·EDTA.
  3. c. Duplex concentration: 2 μM.
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BMC Chemistry

ISSN: 2661-801X

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