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Table 1 Thermodynamic parameters of RNA/DNA duplexes 1/2, 1/7, and 1/8.a, b

From: Cleavage of pyrene-stabilized RNA bulge loops by trans-(±)-cyclohexane-1,2-diamine

Duplex ΔH (kcal/mol) ΔS (cal/mol·K) Tm (°C)c ΔG298 (kcal/mol)
1/2 -214.7 -607 68.8 ± 0.3 -33.8
1/7 -126.0 -365 55.7 ± 0.4 -17.2
1/8 -83.5 -238 48.5 ± 0.3 -12.6
  1. a. RNA is not labeled with FAM.
  2. b. Buffer: 10 mM PIPES (pH 7.5), 100 mM NaCl, 1 mM Tris·EDTA.
  3. c. Duplex concentration: 2 μM.
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BMC Chemistry

ISSN: 2661-801X

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