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Table 5 Determination of the studied drugs in Dimetrol® suspension by the updated PLS model and statistical comparison with the reported RP-HPLC method

From: Simultaneous determination of some antiprotozoal drugs in different combined dosage forms by mean centering of ratio spectra and multivariate calibration with model updating methods

Parameters Updated PLS model
  DF METB
Dimetrol ® suspension a
(B.No.906001)
101.19 ± 1.327 99.59 ± 0.981
Standard addition b 99.95 ± 1.233 100.55 ± 1.159
Degree of freedom F-test
(5.050) c
10 10
  0.738 1.026
Degree of freedom 10 10
Student's -t test
(2.228) c
0.200 0.444
  1. a: Average of 6 determinations
  2. b: Average of 3 determinations
  3. c: The values in the parenthesis are the corresponding theoretical values at p = 0.05