Simultaneous determination of some antiprotozoal drugs in different combined dosage forms by mean centering of ratio spectra and multivariate calibration with model updating methods

Table 1 Concentrations of Mebeverine HCl, Diloxanide Furoate and Metronidazole in the calibration and validation sets

Sample No.	MEH (μg mL^-1)	DF (μg mL^-1)	MET (μg mL^-1)
1	3	11	15
2	3	7	25
3	2	15	25
4*	2	11	20
5	4	15	20
6	4	13	25
7*	3	13	10
8	3.5	15	15
9	4	11	10
10	3	9	20
11	2.5	13	20
12	3.5	13	5
13*	3.5	9	10
14*	2.5	9	25
15	2.5	7	15
16	3.5	7	20
17*	2.5	11	5
18	2	13	15
19	3.5	11	25
20	3	15	5
21	4	7	5
22*	2.5	15	10
23	2	7	20
24*	4	9	15
25	2	9	5

ISSN: 2661-801X

Sample No.	MEH (μg mL^-1)	DF (μg mL^-1)	MET (μg mL^-1)
1	3	11	15
2	3	7	25
3	2	15	25
4*	2	11	20
5	4	15	20
6	4	13	25
7*	3	13	10
8	3.5	15	15
9	4	11	10
10	3	9	20
11	2.5	13	20
12	3.5	13	5
13*	3.5	9	10
14*	2.5	9	25
15	2.5	7	15
16	3.5	7	20
17*	2.5	11	5
18	2	13	15
19	3.5	11	25
20	3	15	5
21	4	7	5
22*	2.5	15	10
23	2	7	20
24*	4	9	15
25	2	9	5

Sample No.	MEH (μg mL^-1)	DF (μg mL^-1)	MET (μg mL^-1)
1	3	11	15
2	3	7	25
3	2	15	25
4*	2	11	20
5	4	15	20
6	4	13	25
7*	3	13	10
8	3.5	15	15
9	4	11	10
10	3	9	20
11	2.5	13	20
12	3.5	13	5
13*	3.5	9	10
14*	2.5	9	25
15	2.5	7	15
16	3.5	7	20
17*	2.5	11	5
18	2	13	15
19	3.5	11	25
20	3	15	5
21	4	7	5
22*	2.5	15	10
23	2	7	20
24*	4	9	15
25	2	9	5

Sample No.	MEH (μg mL^-1)	DF (μg mL^-1)	MET (μg mL^-1)
1	3	11	15
2	3	7	25
3	2	15	25
4*	2	11	20
5	4	15	20
6	4	13	25
7*	3	13	10
8	3.5	15	15
9	4	11	10
10	3	9	20
11	2.5	13	20
12	3.5	13	5
13*	3.5	9	10
14*	2.5	9	25
15	2.5	7	15
16	3.5	7	20
17*	2.5	11	5
18	2	13	15
19	3.5	11	25
20	3	15	5
21	4	7	5
22*	2.5	15	10
23	2	7	20
24*	4	9	15
25	2	9	5