Figure 6
Effect of inhibitory compounds on platelet aggregation and TXB 2 level formation in response to collagen. Platelets (0.4x 109 plt/ml) were pretreated with 25 μM of ibuprofen or 50 μM of the inhibitory compounds 3, 4, 7, 8 and 9 then triggered with 0.5 μg/ml collagen. Results represent the aggregation curves of collagen with inhibitory compounds of type I and ibuprofen (A) and compounds of type II (B). TXB2 levels were measured in the supernatant of platelets (C). Results represent 3 experiments. Platelet aggregation by collagen alone versus collagen + inhibitory compounds treated-platelets showed a statistically significant difference (P < 0.02 One Way ANOVA- Bonferroni test).