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Table 3 Enthalpies of solution in phosphate buffer (pH8) and methanol at 25°C, solubility, enthalpies of solvation of Atorvastatin and its solvates

From: Characterisation and evaluation of pharmaceutical solvates of Atorvastatin calcium by thermoanalytical and spectroscopic studies

  Solubility in phosphate buffer pH7 (mg/ml) (SsolpH7 ) Molar enthalpy of solution in its own solvent (kJ mol-1) Enthalpy of solvation ΔsolvH (kJ mol−1) Molar enthalpy of solution (kJ mol-1)
Solvates (ΔsolH2) Atorvastatin Calcium (ATC) (ΔsolH1) Phosphate buffer (pH8) ΔsolH Methanol ΔsolH (methanol)
Atorvastatin Calcium (ATC) 0.166 21.89 19.11
Solvate- I (ATC + 0.5 Isopropyl alcohol)) 0.374 −24.45 −13.52 −10.93 2.51 1.15
Solvate- II (ATC + THF) 0.192 −11.32 10.85 −22.17 14.31 9.95
Solvate- III (ATC + Ethanol) 0.292 −7.61 32.06 35.55 5.46 3.05
Solvate- IV (ATC + 0.5 t-butanol) 0.225 3.16 34.85 −31.69 11.50 5.45
Solvate- V (ATC + methanol) 0.341 2.12 16.35 −19.98 3.85 2.12
Solvate-VI (ATC + 1 Acetone +0.5 Ethanol) 0.245 −10.80 41.20 −48.40 8.35 5.1
Solvate-VII (ATC + 0.5 Ethanol + Water) 0.185 −4.25 112.49 −116.74 16.98 12.7
Solvate- VIII (ATC + 1- butanol) 0.387 −4.6 13.36 −17.96 1.17 0.57