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Table 6 Influence of small variations in the assay conditions on the analytical performance of the proposed spectrophotometric method for determination of CIN using NQS reagent

From: Novel spectrophotometric method for determination of cinacalcet hydrochloride in its tablets via derivatization with 1,2-naphthoquinone-4-sulphonate

Parameters

Recovery (% ± SD)a

Recommended conditionsb

100.57 ± 1.51

NQS concentration (%, w/v)

 

   0.4

100.06 ± 0.53

   0.6

100.20 ± 0.34

Buffer solution (pH)

 

   8.3

98.95 ± 0.67

   9.7

100.55 ± 0.68

Temperature (°C)

 

   20

99.24 ± 1.04

   30

101.15 ± 0.48

Reaction time (min)

 

   5

99.87 ± 0.26

   15

101.41 ± 0.66

  1. a Values are mean of 3 determinations.
  2. b The recommended conditions are given in the Experimental Section.
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BMC Chemistry

ISSN: 2661-801X

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