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Table 1 Summary for the optimization of variables affecting the reaction of CIN with NQS reagent employed in the development of the proposed spectrophotometric method

From: Novel spectrophotometric method for determination of cinacalcet hydrochloride in its tablets via derivatization with 1,2-naphthoquinone-4-sulphonate

Variable

Studied range

Optimum

NQS concentration (%, w/v)

0.1 - 0.9

0.5

pH

6 - 10

8.5

Temperature (°C)

25 - 60

25

Time (min)

5 - 35

10

Diluting solvent

Differenta

Water

Measuring wavelength (nm)

400 - 600

490

  1. a solvents were: methanol, ethanol, isopropanol, acetone, acetonitrile, and 1,4-dioxane.