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Table 1 Validation parameters for first and ratio first derivative spectroscopic methods

From: Simultaneous determination of moxifloxacin and cefixime by first and ratio first derivative ultraviolet spectrophotometry

 Parameters assessed

Method D1*

Method RD1**

 

MOX

CEF

MOX

CEF

Beer’s law range (μg /mL )

1-16

1-16

1-15

1-15

Wavelength (nm)

287.0

317.9

359.3

269.6

Correlation Coefficent(r2)

0.9992

0.9992

0.9991

0.9993

Slope

0.00362

0.00114

0.1807

0.0109

Intercept

5.08x10-4

−4.32x10-5

−0.0196

−0.0016

LOD

0.22

0.32

0.24

0.14

LOQ

0.75

0.95

0.70

0.43

Intraday precision (%RSD)

0.87

1.35

0.92

0.80

Interday precision(%RSD)

1.56

1.79

1.38

1.18

  1. * First derivative Spectrophotometric method. **First derivative of the ratio spectra.
  2. MOX-Moxifloxacin HCl, CEF- Cefixime trihydrate. %RSD : Percent Relative Standard Deviation.
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BMC Chemistry

ISSN: 2661-801X

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