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Table 4 Summary of degradation studies of FEX using the proposed HPLC method*

From: Development of validated stability-indicating chromatographic method for the determination of fexofenadine hydrochloride and its related impurities in pharmaceutical tablets

  % Recovery Purity angle Purity threshold Match angle Match threshold t R valuesof degradation products
Acid-induced degradation (0.5 N HCl, 80°C, 4 hr) 82.51 0.130 0.347 0.069 1.079 17.48, 19.62, 26.40
Base-induced degradation (0.5 N NaOH, 80°C, 4 hr) 89.54 0.145 0.425 0.081 1.105 -
Oxidative degradation 89.73 0.125 0.332 0.084 1.071 -
   -3% H2O2       
   (80°C, 2 hr)       
-30% H2O2 (80 s°C, 2 hr) 22.01 0.145 0.352 0.035 1.077 11.83
Photochemical degradation 98.89 0.121 0.341 0.111 1.076 -
   -Direct daylight       
   (7 days)       
-UV at 254 nm (8 hr) 98.66 0.111 0.342 1.076 1.098 -
Thermal degradation (80°C, 8 hr) 98.40 0.118 0.411 0.101 1.098 -
  1. *FEX peak was defined as main peak since match angle was less than match threshold and also as pure peak since purity angle was less than purity threshold under all forced tests.