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Table 1 Chromatographic characteristics of FEX and its four related impurities (A-D) using the proposed HPLC method

From: Development of validated stability-indicating chromatographic method for the determination of fexofenadine hydrochloride and its related impurities in pharmaceutical tablets

Compound

t R

RRT

N

k

α

R s

T f

RRF

RSD

(area precision)

FEX

10.72

-

4940

6.2

  

1.000

-

0.40

     

1.15

2.3

   

Impurity A

11.99

1.12

5900

7.10

  

1.033

1.04

0.54

     

1.19

3.52

   

Impurity B

14.01

1.31

6210

8.47

  

1.123

0.91

0.65

     

1.20

4.39

   

Impurity C

16.53

1.81

8398

10.17

  

1.009

0.90

0.52

     

1.31

7.54

   

Impurity D

21.23

2.00

9500

13.34

  

1.189

0.91

0.66

  1. t R : Retention time in min.
  2. RRT: Relative retention time, of each impurity relative to FEX peak.
  3. K: Capacity factor. α: Selectivity, between each two successive peaks.
  4. R s :Resolution, between each two successive peaks. T f :Tailing factor.
  5. RRF: relative response factor of each impurity relative to FEX peak.
  6. RSD: relative standard deviation for area of five injections (instrument precision)
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BMC Chemistry

ISSN: 2661-801X

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