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Table 1 Chromatographic characteristics of FEX and its four related impurities (A-D) using the proposed HPLC method

From: Development of validated stability-indicating chromatographic method for the determination of fexofenadine hydrochloride and its related impurities in pharmaceutical tablets

Compound t R RRT N k α R s T f RRF RSD (area precision)
FEX 10.72 - 4940 6.2    1.000 - 0.40
      1.15 2.3    
Impurity A 11.99 1.12 5900 7.10    1.033 1.04 0.54
      1.19 3.52    
Impurity B 14.01 1.31 6210 8.47    1.123 0.91 0.65
      1.20 4.39    
Impurity C 16.53 1.81 8398 10.17    1.009 0.90 0.52
      1.31 7.54    
Impurity D 21.23 2.00 9500 13.34    1.189 0.91 0.66
  1. t R : Retention time in min.
  2. RRT: Relative retention time, of each impurity relative to FEX peak.
  3. K: Capacity factor. α: Selectivity, between each two successive peaks.
  4. R s :Resolution, between each two successive peaks. T f :Tailing factor.
  5. RRF: relative response factor of each impurity relative to FEX peak.
  6. RSD: relative standard deviation for area of five injections (instrument precision)