Utility of certain nucleophilic aromatic substitution reactions for the assay of pregabalin in capsules

BMC Chemistry

Table 3 Validation of the proposed methods for the determination of PG pure form

Parameter	Method I			Method II
	Pregabalin concentration (μg mL^-1 )			Pregabalin concentration (μg mL^-1 )
	8.0	15.0	20	2	4	6
Intraday
% Found	100.37	100.77	100.76	98.72	101.75	98.34
	101.23	98.20	101.02	101.29	98.24	100.89
	98.94	101.80	99.24	101.43	99.72	101.48
Mean ()	100.18	100.26	100.34	100.48	99.90	100.24
S.D.	1.16	1.85	0.96	1.53	1.76	1.67
% RSD	1.16	1.85	0.96	1.52	1.76	1.67
% Error	0.67	1.07	0.55	0.88	1.02	0.96
Inter-day
% Found	100.47	99.09	100.32	99.37	98.90	102.26
	99.53	101.48	99.71	100.63	101.10	100.75
	100.78	100.91	101.16	98.95	101.10	99.25
Mean ()	100.26	100.49	100.40	99.65	100.37	100.75
S.D.	0.65	1.25	0.73	0.87	1.27	1.51
% RSD	0.65	1.24	0.73	0.88	1.27	1.49
% Error	0.38	0.72	0.42	0.51	0.73	0.86

ISSN: 2661-801X