Skip to main content

Table 8 Activation parameters for the hydride transfer catalyzed by Escherichia coli dihydrofolate reductase in various solvents

From: On the curvature in logarithmic plots of rate coefficients for chemical reactions

Solvent a Δu TS / kcal mol-1 σ
H2O 1 2.73 108
(1.26 108)
8.29
(0.23)
1.65 10-2
(1.14 10-2)
7.02 10-2
(1.92 10-3)
MeOH 17% 24
(18.08)
1.46 104
(4.78 104)
20.95
(9.92)
8.20 10-3
(1.03 10-2)
0.67
(0.11)
MeOH 33% 1 1.46 107
(8.52 106)
6.72
(0.27)
1.35 10-2
(1.41 10-2)
8.66 10-2
(3.60 10-3)
MeOH 50% 1 3.04 106
(3.89 106)
6.37
(0.42)
3.67 10-2
(1.74 10-2)
8.98 10-2
(6.18 10-3)
glycerol 17% 1 3.45 109
(8.72 108)
9.74
(0.14)
7.22 10-2
(7.56 10-3)
5.98 10-2
(8.51 10-4)
glycerol 33% 96
(18.15)
1.06 103
(1.13 103)
62.22
(10.18)
2.39 10-2
(7.37 10-3)
0.90
(3.09 10-2)
glycerol 50% 169
(20.18)
3.87 102
(5.56 101)
104.67
(11.37)
3.37 10-2
(8.57 10-3)
0.94
(1.09 10-2)
sucrose 17% 3
(1.00)
4.65 106
(9.44 106)
8.80
(0.48)
1.96 10-2
(1.76 10-2)
0.20
(5.53 10-2)
sucrose 30% 108
(44.96)
4.38 102
(1.10 103)
64.78
(24.83)
5.79 10-2
(9.23 10-3)
0.97
(6.75 10-2)
  1. Standard deviations are given in parentheses.
\