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Table 4 Thermodynamic descriptions of the bPBPs.1

From: Hydrogen bond networks determine emergent mechanical and thermodynamic properties across a protein family

 

LAOBP

HBP

GBP

PhBP

PDB ID

1LST

2LAO*

1HSL

1WDN

1GGG*

1IXH

T m (K)

385

376

336

336

297

386

C p max(kcal/mol·K)

113.6

70.8

38.5

26.4

8.7

174.1

Barrier (kcal/mol)

13.6

8.4

4.3

2.6

0.0

13.1

θnat

0.8

0.9

1.0

0.8

n/a2

0.9

θTS

1.2

1.3

1.3

1.1

n/a

1.2

θunf

2.1

1.9

1.8

1.6

n/a

2.0

  1. 1All four bPBP homologs have been crystallized in the ligated conformation. Additionally, two bPBP homologs (marked with asterisks) have been crystallized in the open apo conformation. 2 The apo GBP structure is predicted to have a continuous transition between folded and unfolded.
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BMC Chemistry

ISSN: 2661-801X

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