%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
2020-02-12T00:55:57+05:30
Springer
2020-02-14T16:12:37+01:00
2020-02-14T16:12:37+01:00
Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
Thymoquinone,PLGA-nanoparticles,Epilepsy,UHPLC-PDA,Brain bioavailability and pharmacokinetic
application/pdf
https://doi.org/10.1186/s13065-020-0664-x
Springer International Publishing
BMC Chemistry, https://doi.org/10.1186/s13065-020-0664-x
Thymoquinone
PLGA-nanoparticles
Epilepsy
UHPLC-PDA
Brain bioavailability and pharmacokinetic
A bioanalytical UHPLC based method used for the quantification of Thymoquinone-loaded-PLGA-nanoparticles in the treatment of epilepsy
Niyaz Ahmad
Rizwan Ahmad
Sadiq Al Qatifi
Mahdi Alessa
Hassan Al Hajji
Md Sarafroz
10.1186/s13065-020-0664-x
2010-04-23
true
springer.com
springerlink.com
https://doi.org/10.1186/s13065-020-0664-x
10.1186/s13065-020-0664-x
2661-801X
journal
BMC Chemistry
The Author(s)
2010-04-23
true
10.1186/s13065-020-0664-x
noindex
springer.com
springerlink.com
VoR
uuid:8e2a24dc-70c1-48cb-aa6a-5ff919180c5c
uuid:0e3a474c-5fc0-4738-9f04-a319cf9c9896
default
1
converted
uuid:4524b91f-6ad6-4a9a-b0a4-d2eb7a0fcccd
converted to PDF/A-2b
pdfToolbox
2020-02-12T00:57:26+05:30
2
B
Niyaz Ahmad
http://orcid.org/0000-0003-1874-6006
http://ns.adobe.com/pdfx/1.3/
pdfx
Adobe Document Info PDF eXtension Schema
external
Mirrors crossmark:MajorVersionDate
CrossmarkMajorVersionDate
Text
external
Mirrors crossmark:CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
Mirrors crossmark:DOI
doi
Text
external
Mirrors crossmark:CrosMarkDomains
CrossMarkDomains
seq Text
internal
A name object indicating whether the document has been modified to include trapping information
robots
Text
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://crossref.org/crossmark/1.0/
crossmark
Crossmark Schema
internal
Usual same as prism:doi
DOI
Text
external
The date when a publication was publishe.
MajorVersionDate
Text
internal
CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
CrossMarkDomains
CrossMarkDomains
seq Text
http://prismstandard.org/namespaces/basic/2.0/
prism
Prism Schema
external
This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.
url
URI
external
The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL).
doi
Text
external
ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.
issn
Text
internal
Volume number
volume
Text
internal
Issue number
number
Text
internal
Starting page
startingPage
Text
internal
Ending page
endingPage
Text
external
The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary.
aggregationType
Text
external
Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”
publicationName
Text
external
Copyright
copyright
Text
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
DocumentID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
Springer Nature ORCID Schema
http://springernature.com/ns/xmpExtensions/2.0/
sn
authorInfo
Bag AuthorInformation
external
Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.
AuthorInformation
http://springernature.com/ns/xmpExtensions/2.0/authorInfo/
author
Specifies the types of author information: name and ORCID of an author.
name
Text
Gives the name of an author.
orcid
URI
Gives the ORCID of an author.
http://www.niso.org/schemas/jav/1.0/
jav
NISO
external
Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record
journal_article_version
Closed Choice of Text
endstream
endobj
3 0 obj
<>
endobj
7 0 obj
[9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R]
endobj
9 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR15:114)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[214.621 704.391 224.46 692.224]>>
endobj
10 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR17:116)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[230.389 704.391 240.228 692.224]>>
endobj
11 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR9:108)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[227.698 632.391 232.618 620.224]>>
endobj
12 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR9:108)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[132.796 548.391 137.715 536.224]>>
endobj
13 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR18:117)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[144.92 512.391 154.759 500.224]>>
endobj
14 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR20:119)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[160.688 512.391 170.527 500.224]>>
endobj
15 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR21:120)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[199.095 452.391 208.934 440.224]>>
endobj
16 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR23:122)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[214.863 452.391 224.702 440.224]>>
endobj
17 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR24:123)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[86.4201 296.391 96.2592 284.224]>>
endobj
18 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR28:127)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[102.188 296.391 112.027 284.224]>>
endobj
19 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR26:125)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[59.8876 92.3906 69.7268 80.2239]>>
endobj
20 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR28:127)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[75.6557 92.3906 85.4949 80.2239]>>
endobj
21 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR29:128)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[397.669 668.391 407.508 656.224]>>
endobj
22 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR30:129)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[324.497 608.391 334.336 596.224]>>
endobj
23 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR31:130)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[386.952 572.391 396.792 560.224]>>
endobj
24 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR31:130)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[438.58 536.391 448.419 524.224]>>
endobj
25 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR33:132)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[454.348 536.391 464.188 524.224]>>
endobj
26 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR31:130)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[503.719 476.391 513.558 464.224]>>
endobj
27 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR33:132)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[519.487 476.391 529.326 464.224]>>
endobj
6 0 obj
<>/ProcSet[/PDF/Text]/Font<>/XObject<>>>
endobj
4 0 obj
<>stream
x\rVzεIzs*0e 135Ux&JQ$b2)Z+&hrD8_۫D>QW$*UWw+n*NueZH$-U3u}h}ߪLTZ,~ˢUZu*NB]5pEms
KyQ_p__ÅԻMeZǫ*zVu%YrPi_^]{JqOzf,PVx:-ʸ8Y%eV-)oC-.h2/Է?eDZfȢE [ܴ*ԛe/U\G-~VhHP*[yW.ػ'J?D?k +H̝=>U{#4D]q-{x@7(=<#"Yz2jr pMVAujMS:M| y5-*RFKhp0m*XViZKUr_%*ΗJQR<:{?v[Y0,j6HJqaGܺo+|`te7jq
ok %$arxg3uwçn?s}]iG=r:tȐsXMsR,OsQ"n4
[[qZCg|dnu8vAf8KHVm@A94+Q`;Hqg^ &aXͭK{6QW3wF5::WiZ5y45T\f_ɔHM|:Q!|7
5h3U$JYFG"6M1gF~S4eF{qT6+ ""O}TC+
([~R%ӗR؍WVuց7'V·`DP-gĴ˛=Fkh3ft@[iB"^aT~ʑa]o|Z851t+ZQ{Y*GlvUt@ilZu@2WHb=$o߾^/ݭz诽m%ؗv׳䶓.( 7(6*#~I)BDBRDz4՚]IG?̀iǞ[EnJRch}Ґ`l2
`dkӼ˭w-
[1$RvД32\
r7^Nܗi!b EVs8lנ:{qt&>v+;X81d
kñŊh
*2#]{LJjI\.Ρ3.}Ǔjev9\C28 Ӛb"ab{ϝZAA*.VoFpߺQdEKfC)p$1l`F;+%a=-JSNA5D^"]f0g7f̩JO`!QD;7&_]I&0[N6m?ɹOHι.]%(/#5."^>Ɖ^e|jxn>yth-X^9I]@fxyTlX~ao;]\n?7=Cߛnv"̏Z@_[{(=Hbƺv8Jٖ}@Y3Ayyqy(v:cL6GVg$bmYӂ^;kHvH K"ttzvq D=hK(NcOH9,KEJŢ$ڊEZ0L ٝ(B|RMQBN27HV49]ʸ*
leob:>zЙ
*z5ըeIL<zqcW3Dq{1=[ rH
$0YJKf抭|#f*?gbu14u@Ϫ$?Wv;ʉ-ۺo
䶄;#I'yCp`2ґ&kC-/@ ~3_7nD&[_702iCMb(@DkۯrP!I9ߔ|fA-5f%V[0B9>I1N76'E(מT2bh]rk- l[nݯ"#b*uN }&*$:Ov{VI6-g>nK%|N4"ZӀDWW5:*d5UtIdm˰E
՛ G%Baeu|Rja:⟑fZሔMן%e>),NK-,|pc攷%:@>vbGv=^J*nqyaոDsگCGRX3yz~lNWPD}ϒMX}Ҙ*=Hҋo{nJ 5P0U%pZi\}3mFFՐ7'@$UU*͛dYȣ c̫m
03kX, :Emtы`ph~[$0@HVY8DpE5*KthgÆ9G8{1LlGWYr-'Ƭ7`Y-ICƁnED[A#<&y',p3ۯHY:q\dy.Tvn`s9,wK)r`ɪ̒&ؒ22e^U1= H<L춣 Xi@rGTB4N
C.qdW;6hs#>v$RϰLk"%rT8{%'E3P%KNp0Y/xչO\}Q-#dn6G3d##1t[{`^ů>ν1x\A6s oxOxzj1]9uMGYtwgW6 +9;n
Itޟ)iMƏ'Ђ9\7c0\(z&e'=L>=ԠW#2-G P :xbn?mX3czlZΜkw\C@&F%8Kg&
'ft9JN0Ni,ZY3(qٟ:XȝWd
|Zǧ4Y7Yip$~M*|+V[ѥ)A5BR=am&4ƳDר8uK~w1'&.n.F$gƹ-IN~fD xs%}AMɑk^swOX9'N|NiA&tZwM륋^Dz݁1VL$&/Of"LA<]=겇3fAC@V[2k(*?|ߠ+0~s)ImdhA>&/GzJ67Xzrޓըڹu!$>y3%uO
`.HN2\FJvBx3q'G.1B۱2hL}+ O&⅄dbv]G]<Đpzq~3ϩP>*K7F.оbŕhm3*xrc+ X03l>܄|B*#':[&ӣ4yb4~ɽo o.4:U6o+C䔵mgvvVܪWz4̍i^3*w4twΠlV6qt" lvO*ltQĝ5|̕B_61q=T.&}=x?j5>ӧքOd*6Om=Kez?Sxf=5ih#EeSÏQpDN
C\u_TRz7?lK.zs3;B+ib}[C0N)/uc1nس?| 20uS+t D=m8<*╀ %XFX(3%ЉO"@CH3c-4OCoq9E9)a"8B\FKЅH+~8xBK.Ӛ͆C^Q&Zu"lFjςߣ!5ك/97K/w]lRjXxЃ;o )낌=.n~;d
endstream
endobj
43 0 obj
<>
endobj
47 0 obj
[48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R]
endobj
48 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR34:133)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[260.501 552.875 270.341 540.709]>>
endobj
49 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR35:134)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[275.283 552.875 285.122 540.709]>>
endobj
50 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:Tab1:44)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[283.397 238.517 288.317 226.35]>>
endobj
51 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR28:127)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[200.82 130.517 210.659 118.35]>>
endobj
52 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:CR36:135)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[215.515 130.517 225.354 118.35]>>
endobj
53 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:Fig1:45)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[267.753 118.517 272.673 106.35]>>
endobj
54 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:Tab1:44)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[81.1924 106.517 86.112 94.35]>>
endobj
55 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:Tab1:44)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[329.155 541.178 334.074 529.011]>>
endobj
56 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:Tab1:44)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[331.133 433.178 336.053 421.011]>>
endobj
57 0 obj
<>/Subtype/Link/Dest(13065_2020_664_Article.indd:Fig2:49)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[400.58 300.335 405.499 288.168]>>
endobj
46 0 obj
<>/ProcSet[/PDF/Text]/Font<>/XObject<>>>
endobj
44 0 obj
<>stream
x\moF!9_fn#iYk-(bEw؟{Udm$LX/zꢝoG-^!pWG9OG }8aAdD:d~%㑛]p&Llzp/V7a'b{4.\sX,p7kYqY9f
iݖDYɽ_/+okY]ST3lCӔNVe=~*o3'ƨ]AP0;t 2C9`J#/YQrMuMRE? b,ÓC<>7$i3ڽ;rEMڷJc~Ĺ/ `D2{_h@PP%#rorv@Yvf<#߫bܖ+-.+\ʜKQ鿃hY5snk|় Ay*A,Q:=F')y
gh;sj^.e=¬cWW`
V{뮋E0ʪ\sM+0w˛p>,~:&b#O}n$|"5BbtȎ]Nnv
I1QTm^fҲ䄓0
+
]
4YY̔S6Gixe50 OZJ=5GTBߟhEGdzPާNKO>=w~9b3w"rGw^Q,j܂6z[bY2wP?wUMxK|lܼqPcR:,n@Z;gOk(+c
:? ivS:[J+7J-*ki}5`
uMRi/қzaA
CHӮqc|-lVN NF7$'"]T6,mx:>@?mfaɸ9}pzL'!&