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Organic Chemistry

This section publishes articles in all areas of organic chemistry including organic synthesis, bioorganic chemistry, physical organic chemistry, stereochemistry, structure-activity relationships, synthetic methods, organometallic chemistry, and natural product chemistry.

  1. The tri-component synthesis of novel chiral benzimidazole Mannich bases, by reaction between benzimidazole, aqueous 30% formaldehyde and an amine, the biological evaluation and DFT studies of the new compounds...

    Authors: Maria Marinescu, Ludmila Otilia Cinteză, George Iuliu Marton, Mariana-Carmen Chifiriuc, Marcela Popa, Ioana Stănculescu, Christina-Marie Zălaru and Cristina-Elena Stavarache

    Citation: BMC Chemistry 2020 14:45

    Content type: Research article

    Published on:

  2. In this study, 5-amino-nicotinic acid derivatives (1–13) have been designed and synthesized to evaluate their inhibitory potential against α-amylase and α-glucosidase enzymes. The synthesized compounds (1–13) exh...

    Authors: Muhammad Nawaz, Muhammad Taha, Faiza Qureshi, Nisar Ullah, Manikandan Selvaraj, Sumaira Shahzad, Sridevi Chigurupati, Abdul Waheed and Fadiah Ammar Almutairi

    Citation: BMC Chemistry 2020 14:43

    Content type: Research article

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  3. Thiazoles, thiazolidinones and azetidinones are highly ranked amongst natural and synthetic heterocyclic derivatives due to their great pharmaceutical potential.

    Authors: Essam M. Hussein, Reem I. Alsantali, Moataz Morad, Rami J. Obaid, Hatem M. Altass, Ali Sayqal, Mohamed A. S. Abourehab, Amal A. Elkhawaga, Ahmed S. M. Aboraia and Saleh A. Ahmed

    Citation: BMC Chemistry 2020 14:42

    Content type: Research article

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  4. A new series of pyrazole, bipyridine, N-amide derivatives and Schiff bases was synthesized using compound 2-(3-cyano-6- (thiophen-2-yl)-4,4′- bipyridin-2-yloxy) acetohydrazide (3) as a starting material. The comp...

    Authors: Hossa F. Al Shareef

    Citation: BMC Chemistry 2020 14:40

    Content type: Research article

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  5. A new series of indole-based-sulfonamide derivatives (A1–A8) was synthesized by treating 5-fluoro-1H-indole-3-carbohydrazide with different aryl-sulfonyl chloride in the presence of pyridine. All synthesized deri...

    Authors: Mohamed Ibrahim, Muhammed Taha, Noor B. Almandil, Abdel-Nasser Kawde and Muhammad Nawaz

    Citation: BMC Chemistry 2020 14:38

    Content type: Research article

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  6. Eugenia punicifolia (Kunth) D. C. (Myrtaceae) has been showing interesting biological activities in the literature which was correlated to its phenolic compounds. In the sense of a better recovering of phenolics ...

    Authors: Catarina dos Santos, Andressa Lie Mizobucchi, Bruna Escaramboni, Bruno Pereira Lopes, Celio Fernando Figueiredo Angolini, Marcos Nogueira Eberlin, Karina Alves de Toledo and Eutimio Gustavo Fernández Núñez

    Citation: BMC Chemistry 2020 14:34

    Content type: Research article

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  7. Three new phenylethanol glycosides (1-3) and one known analogue (4) were isolated from the seeds of Aesculus chinensis Bge. var. chekiangensis. To the best of our knowledge, this represents the first isolation of...

    Authors: Nan Zhang, Di Liu, Shuxiang Wei, Shijie Cao, Xinchi Feng, Kai Wang, Liqin Ding and Feng Qiu

    Citation: BMC Chemistry 2020 14:31

    Content type: Research article

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  9. Chemical investigation of the essential oil obtained from the heartwood of Erythroxylum monogynum Roxb. yielded three beyerene type diterpenoids ent-beyer-15-ene (1), ent-beyer-15-en-19-ol (erythroxylol A) (2) an...

    Authors: T. M. Samantha Gome Tennakoon, G. M. Kamal Bandara Gunaherath, K. Tuley Dayananda De Silva, Chayanika Padumadasa, D. Siril Abeywickrama Wijesundara and Ajita Mahendra Abeysekera

    Citation: BMC Chemistry 2020 14:18

    Content type: Research article

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  10. In the present study, we report the synthesis of various quinoxaline derivatives from direct condensation of substituted aromatic 1,2-diamine with 1,2-dicarbonyl catalyzed by nanostructured pyrophosphate Na2PdP2O

    Authors: Karim Dânoun, Younes Essamlali, Othmane Amadine, Hassan Mahi and Mohamed Zahouily

    Citation: BMC Chemistry 2020 14:6

    Content type: Research article

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  11. A new donor-π-acceptor derived from phenothiazine, namely 2-(2-((10-hexyl-10H-phenothiazin-3-yl)methylene)-3-oxo-2,3-dihydroinden-1-ylidene) malononitrile (PTZON) was synthesized and fully characterized, and i...

    Authors: Fatimah A. M. Al-Zahrani, Reda M. El-Shishtawy, Abdullah M. Asiri, Amerah M. Al-Soliemy, Khloud Abu Mellah, Nahed S. E. Ahmed and Abdesslem Jedidi

    Citation: BMC Chemistry 2020 14:2

    Content type: Research article

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  12. A hybrid magnetic material γFe2O3@Sh@cu2O was easily prepared from Shilajit (Sh) decorated Fe3O4 and copper acetate. The prepared magnetic hybrid material was fully characterized using different analysis, includi...

    Authors: Fereshteh Norouzi and Shahrzad Javanshir

    Citation: BMC Chemistry 2020 14:1

    Content type: Research article

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  15. Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-...

    Authors: Mandlenkosi Robert Khumalo, Surya Narayana Maddila, Suresh Maddila and Sreekantha B. Jonnalagadda

    Citation: BMC Chemistry 2019 13:132

    Content type: Research article

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  16. The side reactions of dehalogenation or C–N coupling tend to occur when halogenated aromatic amines are prepared by catalytic hydrogenation reduction of halogenated aromatic nitro compounds. In this paper, we ...

    Authors: Haichang Guo, Renhua Zheng, Huajiang Jiang, Zhenyuan Xu and Aibao Xia

    Citation: BMC Chemistry 2019 13:130

    Content type: Research article

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  17. Crosslinked sulfonated polyacrylamide (Cross-PAA-SO3H) attached to nano-Fe3O4 as a superior catalyst has been used for the synthesis of 3-alkyl-4-phenyl-1,3-thiazole-2(3H)-thione derivatives through a three-compo...

    Authors: Hossein Shahbazi-Alavi, Sheida Khojasteh-Khosro, Javad Safaei-Ghomi and Maryam Tavazo

    Citation: BMC Chemistry 2019 13:120

    Content type: Research article

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  18. The synthesized Fe3O4@l-arginine showed strong catalytic performance in the one-pot synthesis of spiropyranopyrazoles via the reactions of hydrazines, β-keto esters, isatins, and malononitrile or ethyl cyanoaceta...

    Authors: Mohammad Ali Ghasemzadeh, Boshra Mirhosseini-Eshkevari and Mohammad Hossein Abdollahi-Basir

    Citation: BMC Chemistry 2019 13:119

    Content type: Research article

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  19. Pyrazoles, thiazoles and fused thiazoles have been reported to possess many biological activities. 3-Methyl-5-oxo-4-(2-arylhydrazono)-4,5-dihydro-1H-pyrazole-1-carbothioamides 3a,b (obtained from the reaction of ...

    Authors: Abdelwahed R. Sayed, Sobhi M. Gomha, Fathy M. Abdelrazek, Mohamed S. Farghaly, Shaimaa A. Hassan and Peter Metz

    Citation: BMC Chemistry 2019 13:116

    Content type: Research article

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  21. Cu2O supported on peanut shell (Cu2O@PS) was prepared by the reaction of copper acetate and peanut shell powder as a naturally available biopolymer support. The prepared catalyst was used as an efficient and reus...

    Authors: Zahra Dolatkhah, Abolfazl Mohammadkhani, Shahrzad Javanshir and Ayoob Bazgir

    Citation: BMC Chemistry 2019 13:97

    Content type: Research article

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  22. Sulfonamide derivatives are of great attention due to their wide spectrum of biological activities. Sulfonamides conjugated with acetamide fragments exhibit antimicrobial and anticancer activities. The inhibit...

    Authors: Essam M. Hussein, Munirah M. Al-Rooqi, Shimaa M. Abd El-Galil and Saleh A. Ahmed

    Citation: BMC Chemistry 2019 13:91

    Content type: Research article

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  23. Organic compounds that contain nitrogen are very important intermediates in pharmaceutical and chemical industry. Hydroamination is the reaction that can form C–N bond with high atom economy. The research progres...

    Authors: Jingpei Huo, Guozhang He, Weilan Chen, Xiaohong Hu, Qianjun Deng and Dongchu Chen

    Citation: BMC Chemistry 2019 13:89

    Content type: Review

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  24. The title compounds, 2-azaspiro[4.5]deca-1-one, C9H15NO, (1a), cis-8-methyl-2-azaspiro[4.5]deca-1-one, C10H17NO, (1b), and trans-8-methyl-2-azaspiro[4.5]deca-1-one, C10H17NO, (1c), were synthesized from benzoic a...

    Authors: Tobias Krueger, Alexandra Kelling, Torsten Linker and Uwe Schilde

    Citation: BMC Chemistry 2019 13:69

    Content type: Research article

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  25. Following publication of the original article [1], the authors reported an error in Schemes 1 and 2 and repeated line in subsection “Bis(ligand) nickel(II) chelate (NiL12)”.

    Authors: Mei Luo, Jing Cheng Zhang, Hao Yin, Cheng Ming Wang, Susan Morris-Natschke and Kuo-Hsiung Lee

    Citation: BMC Chemistry 2019 13:63

    Content type: Correction

    Published on:

    The original article was published in BMC Chemistry 2019 13:51

  26. The general approach to the synthesis of metal complexes begins with ligand synthesis, followed by ligand reaction with metal salts to afford organometallic complexes. Our research group first reported a one-p...

    Authors: Mei Luo, Jing Cheng Zhang, Hao Yin, Cheng Ming Wang, Susan Morris-Natschke and Kuo-Hsiung Lee

    Citation: BMC Chemistry 2019 13:51

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Chemistry 2019 13:63

  27. Pyrazolines show different biological activities. In recent years, interest in the chemistry of hydrazonoyl halides has been renewed. 1,3,4-Thiadiazoles are one of the most common heterocyclic pharmacophores w...

    Authors: Abdou O. Abdelhamid, Ibrahim E. El Sayed, Yasser H. Zaki, Ahmed M. Hussein, Mangoud M. Mangoud and Mona A. Hosny

    Citation: BMC Chemistry 2019 13:48

    Content type: Research article

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  28. The present study reveals the robust and facile methodology for the synthesis of massively selective dispiro-3-phenylpyrrolothiazole hybrids via one-pot 1,3-dipolar cycloaddition reaction by environmentally su...

    Authors: Govindasami Periyasami, Karuppiah Ponmurugan, Natarajan Arumugam, Raju Sureshkumar, Mostafizur Rahaman, Durairaju Periyan, Naif Abdullah Al-Dhabi, Shaykha Alzahly and Ali Aldalbahi

    Citation: BMC Chemistry 2019 13:42

    Content type: Research article

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  29. A facile and convenient method for the synthesis of acridines and its derivatives was developed through one-pot, three-component condensation reaction of aromatic aldehydes, 5,5-dimethyl-1,3-cyclohexanedione, ...

    Authors: M. Mujahid Alam, Ahmed T. Mubarak, Mohammed A. Assiri, S. Merajuddin Ahmed and Ahmed M. Fouda

    Citation: BMC Chemistry 2019 13:40

    Content type: Research article

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  30. A convenient approach for (1E,3E)-1,4-diarylbuta-1,3-dienes via intermolecular Heck reaction of olefins and β-bromostyrenes promoted by μ-OMs palladium–dimer complex has been successfully developed. The products ...

    Authors: Xueliang Zhou, Yuan Zhou, Qiang Zhu, Huimin Chen, Nan Wu, Xiangru Wen and Zhou Xu

    Citation: BMC Chemistry 2019 13:39

    Content type: Research article

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  31. Thiazole is a core structural motif presents in a wide range of natural products. Thiazole derivatives also have a wide range of medicinal and biological properties.

    Authors: Mona A. Hosny, Yasser H. Zaki, Wafaa A. Mokbel and Abdou O. Abdelhamid

    Citation: BMC Chemistry 2019 13:37

    Content type: Research article

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  32. 4-Thiazolidinone ring is reported to have almost all types of biological activities. Also, it present in many marketed drugs.

    Authors: Yahia N. Mabkhot, Mohammed M. Alharbi, Salim. S. Al-Showiman, Saied M. Soliman, Nabila A. Kheder, Wolfgang Frey, Abdulrhman Asayari, Abdullatif Bin Muhsinah and H. Algarni

    Citation: BMC Chemistry 2019 13:35

    Content type: Research article

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  33. penta-1,4-diene-3-one oxime ether and quinazolin-4(3H)-one derivatives possess favorable agricultural activities. Aiming to discover novel molecules with highly-efficient agricultural activities, a series of pent...

    Authors: Lijuan Chen, Xiaobin Wang, Xu Tang, Rongjiao Xia, Tao Guo, Cheng Zhang, Xiangyang Li and Wei Xue

    Citation: BMC Chemistry 2019 13:34

    Content type: Research article

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  35. Indole based thiadiazole derivatives (1–22) have synthesized, characterized by NMR and HREI-MS and evaluated for β-Glucuronidase inhibition. All compounds showed outstanding β-glucuronidase activity with IC50 val...

    Authors: Noor Barak Almandil, Muhammad Taha, Mohammed Gollapalli, Fazal Rahim, Mohamed Ibrahim, Ashik Mosaddik and El Hassane Anouar

    Citation: BMC Chemistry 2019 13:14

    Content type: Research article

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  36. Dihydrofolate reductase (DHFR) is an important target for antimetabolite class of antimicrobials because it participates in purine synthesis. 2-mercaptobenzimidazole (2MBI) has similar structural features as p...

    Authors: Sumit Tahlan, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah, Vasudevan Mani and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:12

    Content type: Research article

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  37. This work deals with the synthesis and characterization of the novel 5-((5-chloro-1H-indol-2-yl)methylene)-1,3-diethyl-2-thioxodihydro-pyrimidine-4,6(1H,5H)-dione π-bridge (D–A–D) donor–acceptor–donor compound. I...

    Authors: Mezna Saleh Altowyan, Assem Barakat, Abdullah Mohammed Al-Majid, Hazem A. Ghabbour, Abdelkader Zarrouk and Ismail Warad

    Citation: BMC Chemistry 2019 13:11

    Content type: Research article

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  38. The resinous exudates from Escallonia illinita by products was characterized by FT-IR, NMR and HRMS. Six compounds were isolated and identified as follows: 1,5-diphenylpent-1-en-3-one (1), 4-(5-hydroxy-3,7-dimeth...

    Authors: Iván Montenegro, Elizabeth Sánchez, Enrique Werner, Patricio Godoy, Yusser Olguín, Nelson Caro, Nicole Ehrenfeld and Alejandro Madrid

    Citation: BMC Chemistry 2019 13:1

    Content type: Research article

    Published on:

BMC Chemistry

ISSN: 2661-801X

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