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Medicinal Chemistry

This section publishes articles in all areas of medicinal chemistry including drug discovery, QSAR studies and applications, pharmacokinetics, design, synthesis, and evaluation of biologically active compounds, prodrugs, diagnostic agents and other pharmacological tools, structural and molecular biological studies and computational methods and applications in medicinal chemistry.

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  1. To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a new series of 1,2,3-triazole-chromenone derivatives were designed and synthesized based on the multi target-directed ligands ...

    Authors: Hajar Karimi Askarani, Aida Iraji, Arezoo Rastegari, Syed Nasir Abbas Bukhari, Omidreza Firuzi, Tahmineh Akbarzadeh and Mina Saeedi

    Citation: BMC Chemistry 2020 14:64

    Content type: Research article

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  2. Non-steroidal anti-inflammatory drugs are among the most used drugs. They are competitive inhibitors of cyclooxygenase (COX). Twelve novel compounds (aryl acetate and aryl acetic acid groups) were synthesized ...

    Authors: Mohammed Hawash, Nidal Jaradat, Saba Hameedi and Ahmed Mousa

    Citation: BMC Chemistry 2020 14:54

    Content type: Research article

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  3. A series of 2-chloro-5-[(4-chlorophenyl)sulfamoyl]-N-(alkyl/aryl)-4-nitrobenzamide derivatives (5a5v) has been synthesized and confirmed by physicochemical(Rf, melting point) and spectral means (IR, 1HNMR, 13CNM...

    Authors: Samridhi Thakral, Rakesh Narang, Manoj Kumar and Vikramjeet Singh

    Citation: BMC Chemistry 2020 14:49

    Content type: Research article

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  4. Preservatives have to be added in food, pharmaceuticals and cosmetics products to maintain their shelf life. However, the existing chemical based preservatives have been associated with severe side effects tha...

    Authors: Amit Lather, Sunil Sharma and Anurag Khatkar

    Citation: BMC Chemistry 2020 14:41

    Content type: Research article

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  5. Apocynum venetum L. and Eleutherococcus senticosus have been used for hundreds of years to treat hypertension in China. In previous research, there was not a suitable quality control of method for the formulas of...

    Authors: Jie Shen, Kai Yang, Cheng Jiang, Xiao-qiong Ma, Min-xia Zheng and Cai-hua Sun

    Citation: BMC Chemistry 2020 14:35

    Content type: Research article

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  6. In this work, 11 novel compounds based on vaniline and benzylidenehydrazine structure were synthesized with various substituents on phenyl aromatic ring of the molecule and evaluated as tyrosinase inhibitors. ...

    Authors: Aida Iraji, Tina Adelpour, Najmeh Edraki, Mahsima Khoshneviszadeh, Ramin Miri and Mehdi Khoshneviszadeh

    Citation: BMC Chemistry 2020 14:28

    Content type: Research article

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  7. Three series of 2-(4-methylsulfonylphenyl) indole derivatives have been designed and synthesized. The synthesized compounds were assessed for their antimicrobial, COX inhibitory and anti-inflammatory activitie...

    Authors: Ahmed M. M. Shaker, Eman K. A. Abdelall, Khaled R. A. Abdellatif and Hamdy M. Abdel-Rahman

    Citation: BMC Chemistry 2020 14:23

    Content type: Research article

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  8. With the improvement and advance in cancer diagnosis and treatment, the cancer is still a major cause of morbidity and mortality throughout the world. Obviously, new breakthroughs in therapies remain be urgent...

    Authors: Zhen-Hui Xin, Ya-Li Meng, Wen-Jing Jiang, Ya-Peng Li, Li-Ping Ge, Cun-Hui Zhang, Lian-Na Liu and Yan-Fei Kang

    Citation: BMC Chemistry 2020 14:13

    Content type: Research article

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  9. Neurodegenerative disorders follow numerous pathological ways concerning overexpression of monoamine oxidase and formation of reactive oxygen species. The computational design of the piperine derivatives has g...

    Authors: Priyanka Dhiman, Neelam Malik and Anurag Khatkar

    Citation: BMC Chemistry 2020 14:12

    Content type: Research article

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  10. Isolated bioactive components of plants or their raw extract are utilized as complementary or alternate remedy in copious illnesses. The current research was aimed at assessing the activity of aloin A isolated...

    Authors: Addai-Mensah Donkor, Martin Ntiamoah Donkor and Ngmenpone Kuubabongnaa

    Citation: BMC Chemistry 2020 14:8

    Content type: Research article

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  11. A form of β-glucosidase was isolated and purified from fresh Chrysanthemum morifolium (Ramat.) Tzvel. ‘Boju’ (Boju) and its enzymatic properties explored in this study. The purified enzyme and Boju flavonoids wer...

    Authors: Wei Zhang, Yafeng Zuo, Fengqing Xu, Tongsheng Wang, Jinsong Liu and Deling Wu

    Citation: BMC Chemistry 2019 13:128

    Content type: Research article

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    The Correction to this article has been published in BMC Chemistry 2020 14:16

  12. A series of Schiff bases (3.af) bearing benzimidazole moiety was successfully synthesized in ethanol by refluxing Oct-2-ynoic acid (1,3-dihydrobenzimidazole-2-ylidene)amide with substituted amines. Fourier trans...

    Authors: Thierry Youmbi Fonkui, Monisola Itohan Ikhile, Patrick Berka Njobeh and Derek Tantoh Ndinteh

    Citation: BMC Chemistry 2019 13:127

    Content type: Research article

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  13. New fluorinated diaryl ethers and bisarylic ketones were designed and evaluated for their anti-inflammatory effects in primary macrophages.

    Authors: Abeer J. Ayoub, Layal Hariss, Nehme El-Hachem, Ghewa A. El-Achkar, Sandra E. Ghayad, Oula K. Dagher, Nada Borghol, René Grée, Bassam Badran, Ali Hachem, Eva Hamade and Aida Habib

    Citation: BMC Chemistry 2019 13:124

    Content type: Research article

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  14. The transcription factor Nuclear factor erythroid-2-related factor 2 (NRF2) and its principal repressive regulator, Kelch-like ECH-associated protein 1 (KEAP1), are perilous in the regulation of inflammation, ...

    Authors: Murugesh Kandasamy, Kit-Kay Mak, Thangaraj Devadoss, Punniyakoti Veeraveedu Thanikachalam, Raghavendra Sakirolla, Hira Choudhury and Mallikarjuna Rao Pichika

    Citation: BMC Chemistry 2019 13:117

    Content type: Research article

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  15. 2-Aminothiazoles are significant class of organic medicinal compounds utilized as starting material for the synthesis of diverse range of heterocyclic analogues with promising therapeutic roles as antibacteria...

    Authors: Saima Ejaz, Humaira Nadeem, Rehan Zafar Paracha, Sadia Sarwar and Sadaf Ejaz

    Citation: BMC Chemistry 2019 13:115

    Content type: Research article

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  16. In the present study, a series of 2-(4-(2-chloroacetyl)piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives was synthesized and its chemical structures were confirmed by physicoche...

    Authors: Shinky Mehta, Sanjiv Kumar, Rakesh Kumar Marwaha, Balasubramanian Narasimhan, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah and Vasudevan Mani

    Citation: BMC Chemistry 2019 13:113

    Content type: Research article

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  17. In this paper, catalpol propionylated analogs (CPs) were designed as drug ligands of glutathione peroxidase (GSH-Px) based on molecular docking (MD) using Surflex-Docking method. The calculated total scores (T...

    Authors: Chunhong Dong, Shuanglin Liu, Xiaodong Cheng, Qiang Wang, Shiqing Jiang and Guoqing Wang

    Citation: BMC Chemistry 2019 13:109

    Content type: Research article

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  18. The leaves and bark of Syringa oblata Lindl are used as folk medicine which has heat-clearing, detoxifying, dampness-removing and jaundice-relieving effects. There are many studies about leaves of S. oblata becau...

    Authors: Lili Cui, Miyun Hu, Pengran Cao, Yun Niu, Changqin Li, Zhenhua Liu and Wenyi Kang

    Citation: BMC Chemistry 2019 13:108

    Content type: Research article

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  19. Cannabis products (marijuana, weed, hashish) are among the most widely abused psychoactive drugs in the world, due to their euphorigenic and anxiolytic properties. Recently, hair analysis is of great interest ...

    Authors: Iltaf Shah, Bayan Al-Dabbagh, Alaa Eldin Salem, Saber A.A. Hamid, Neak Muhammad and Declan P. Naughton

    Citation: BMC Chemistry 2019 13:106

    Content type: Review

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  20. We have synthesized new series of bisindole analogs (127), characterized by 1HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC50 ...

    Authors: Muhammad Taha, Imad Uddin, Mohammed Gollapalli, Noor Barak Almandil, Fazal Rahim, Rai Khalid Farooq, Muhammad Nawaz, Mohamed Ibrahim, Mohammed A. Alqahtani, Yasser A. Bamarouf and Manikandan Selvaraj

    Citation: BMC Chemistry 2019 13:102

    Content type: Research article

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  21. Thirty-four imidazole-based compounds synthesized by one-pot catalytic method were evaluated for their antifungal and antibacterial activities against several fungal and bacterial strains. None of the compound...

    Authors: Btissam Bouchal, Farid Abrigach, Abdelilah Takfaoui, Manal Elidrissi Errahhali, Mounia Elidrissi Errahhali, Pierre H. Dixneuf, Henri Doucet, Rachid Touzani and Mohammed Bellaoui

    Citation: BMC Chemistry 2019 13:100

    Content type: Research article

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  22. Heterocyclic 1,3-diazine nucleus is a valuable pharmacophore in the field of medicinal chemistry and exhibit a wide spectrum of biological activities. PharmMapper, a robust online tool used for establishing th...

    Authors: Sanjiv Kumar, Deepika Sharma, Balasubramanian Narasimhan, Kalavathy Ramasamy, Syed Adnan Ali Shah, Siong Meng Lim and Vasudevan Mani

    Citation: BMC Chemistry 2019 13:96

    Content type: Research article

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  23. Benzimidazole is a valuable pharmacophore in the field of medicinal chemistry and exhibit wide spectrum of biological activity. Molecular docking technique is routinely used in modern drug discovery for unders...

    Authors: Sumit Tahlan, Sanjiv Kumar, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah, Vasudevan Mani and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:90

    Content type: Research article

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  24. In continuation of our work, new diazenyl chalcones scaffolds (C-18 to C-27) were efficiently synthesized from substituted acetophenone azo dyes (AE) by base catalyzed Claisen–Schmidt condensation with different...

    Authors: Harmeet Kaur, Jasbir Singh and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:87

    Content type: Research article

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  25. Pyrimidine nucleus is a significant pharmacophore that exhibited excellent pharmacological activities. A series of pyrimidine scaffolds was synthesized and its chemical structures were confirmed by physicochem...

    Authors: Sanjiv Kumar, Archana Kaushik, Balasubramanian Narasimhan, Syed Adnan Ali Shah, Siong Meng Lim, Kalavathy Ramasamy and Vasudevan Mani

    Citation: BMC Chemistry 2019 13:85

    Content type: Research article

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  26. Paeonia suffruticosa is an important traditional Chinese herb used to treat osteoarthritis (OA) and oligostilbenes are the main active ingredient of the seeds of P. suffruticosa. The monomer trans-resveratrol of ...

    Authors: Yu-Kun He, Xiao-tong Cen, Shuang-shuang Liu, Hua-ding Lu and Chun-nian He

    Citation: BMC Chemistry 2019 13:72

    Content type: Research article

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  27. In search of effective antimicrobial and cytotoxic agents, a series of indole hybridized diazenyl derivatives (DS-1 to DS-21) was efficiently prepared by condensation of diazotized p-aminoacetophenone with indole...

    Authors: Harmeet Kaur, Jasbir Singh and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:65

    Content type: Research article

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  28. In order to overcome the challenges of microbial resistance as well as to improve the effectiveness and selectivity of chemotherapeutic agents against cancer, a novel series of 4-(4-bromophenyl)-thiazol-2-amin...

    Authors: Deepika Sharma, Sanjiv Kumar, Balasubramanian Narasimhan, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah and Vasudevan Mani

    Citation: BMC Chemistry 2019 13:60

    Content type: Research article

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  29. Diabetes is an emerging metabolic disorder. α-Glucosidase inhibitors, such as acarbose, delay the hydrolysis of carbohydrates by interfering with the digestive enzymes. This action decreases the glucose absorp...

    Authors: Hatem A. Abuelizz, Nor Azman N. I. Iwana, Rohaya Ahmad, El-Hassane Anouar, Mohamed Marzouk and Rashad Al-Salahi

    Citation: BMC Chemistry 2019 13:52

    Content type: Research article

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  30. Nitrogen containing heterocycles are widely used and investigated by pharmaceutical industry, as they are important in discovery and designing of new drug molecules. Drugs with a benzimidazole nucleus possess ...

    Authors: Sumit Tahlan, Sanjiv Kumar, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah, Vasudevan Mani, Ranjana Pathania and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:50

    Content type: Research article

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  31. In search of new antimicrobial and cytotoxic agents, a series of new naphthol diazenyl scaffold based Schiff bases (NS1NS23) was efficiently synthesized by condensation of 2-hydroxy naphthaldehyde azo dyes with ...

    Authors: Harmeet Kaur, Jasbir Singh and Balasubramanian Narasimhan

    Citation: BMC Chemistry 2019 13:49

    Content type: Research article

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  32. The medicinal plant Tirpitzia sinensis has been used by the Zhuang ethnic people in mountainous areas of Southwest China to stop bleeding, invigorate blood circulation, and treat inflammation and wounds. In order...

    Authors: Ronghui Gu, Yuehu Wang, Shibiao Wu, Yeling Wang, Ping Li, Li Xu, Yue Zhou, Ze’e Chen, Edward J. Kennelly and Chunlin Long

    Citation: BMC Chemistry 2019 13:47

    Content type: Research article

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  33. To combat the antimicrobial and anticancer drug resistance by pathogens and cancerous cells, efforts has been made to study the pharmacological activities of newly synthesized N-(4-(4-bromophenyl)thiazol-2-yl)-2-...

    Authors: Deepika Sharma, Sanjiv Kumar, Balasubramanian Narasimhan, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah and Vasudevan Mani

    Citation: BMC Chemistry 2019 13:46

    Content type: Research article

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  34. Urease are responsible for several pathogenic states in human as well as in animals and its inhibition is utmost urgent. Clinically used drugs are associated with many side effects; recently several researches...

    Authors: Ritu Kataria and Anurag Khatkar

    Citation: BMC Chemistry 2019 13:45

    Content type: Research article

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  35. The increased multidrug resistance among antimalarial drugs produces the urgency of potent anti malarial to combat resistant malaria and the malaria burden worldwide. The protein which may prevent the growth o...

    Authors: Jagbir Singh, Rani Mansuri, Sonam Vijay, Ganesh Chandra Sahoo, Arun Sharma and Mahesh Kumar

    Citation: BMC Chemistry 2019 13:43

    Content type: Research article

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  36. Plants have always played important role in treating human and animal diseases as a therapeutic agent for traditional medicine. Through extensive research throughout the world, potential of natural products ha...

    Authors: Ritu Kataria and Anurag Khatkar

    Citation: BMC Chemistry 2019 13:41

    Content type: Research article

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  37. Natural based inhibitors of monoamine oxidase are promising drug candidates for the treatment of several neurodegenerative and neuropsychological disorders including depression, anxiety, Parkinson’s disease an...

    Authors: Priyanka Dhiman, Neelam Malik and Anurag Khatkar

    Citation: BMC Chemistry 2019 13:38

    Content type: Research article

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  38. Plants either in raw form or their isolated bioactive constituents are utilized as complementary and alternative medicine in various disorders. The present study was designed to evaluate chief phytochemical co...

    Authors: Riffat Batool, Muhammad Rashid Khan, Moniba Sajid, Saima Ali and Zartash Zahra

    Citation: BMC Chemistry 2019 13:32

    Content type: Research article

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  39. Mangroves plants and their endophytes represent a natural source of novel and bioactive compounds. In our ongoing research on mangrove endophytes from the Panamanian Pacific Coast, we have identified several b...

    Authors: Dioxelis Lopéz, Lilia Cherigo, Luis C. Mejia, Marco A. Loza-Mejía and Sergio Martínez-Luis

    Citation: BMC Chemistry 2019 13:22

    Content type: Research article

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  40. Proanthocyanidin (PAC) is a promising compound that has displayed its potent antineoplastic properties with a specific intrinsic pathway. This precise us to explore the phyto-preventive effect of PAC against c...

    Authors: Mani Suganya, Balasubramanian Mythili Gnanamangai, Balasubramani Ravindran, Soon Woong Chang, Arokiyaraj Selvaraj, Chandramohan Govindasamy, Mohamed Farouk Elsadek and Ponnusamy Ponmurugan

    Citation: BMC Chemistry 2019 13:21

    Content type: Research article

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