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Table 6 Statistical analysis of the results obtained by the developed univariate, multivariate methods and the reported HPLC methods for the determination of TRI and XIP in pharmaceutical preparation

From: Univariate versus multivariate spectrophotometric data analysis of triamterene and xipamide; a quantitative and qualitative greenly profiled comparative study

Parameters

TRI

XIP

Proposed methods

Reported method

Proposed methods

Reported method

D0

PLS

PCR

ANN

MCR-ALS

HPLC a

FSD

PLS

PCR

ANN

MCR-ALS

HPLCa

Mean b (%)

100.29

99.06

100.17

101.25

100.25

102.00

99.88

100.30

99.12

98.12

100.54

101.00

SD

0.46

0.58

0.46

0.60

0.52

0.33

0.75

0.81

0.72

0.92

0.89

0.62

Variance

0.21

0.33

0.21

0.36

0.27

0.11

0.56

0.65

0.52

0.85

0.80

0.38

n

6

6

6

6

6

6

6

6

6

6

6

6

Student’s t-teste (2.23)c

0.14

0.09

0.13

0.37

0.15

–

0.36

0.60

0.21

0.16

0.98

–

F-value (5.05)c

1.89

2.99

1.88

3.19

2.47

–

1.46

1.69

1.35

2.20

2.07

–

  1. aHPLC method: phosphate buffer pH 3.5 and acetonitrile (30:70% v/v) at flow rate of 1.0 mL/min, detection at 254.0 nm (11)
  2. bAverage of 6 experiments
  3. c Figures between parentheses represent the corresponding tabulated values of t and F at P=0.05
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BMC Chemistry

ISSN: 2661-801X

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