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Table 4 Application of the proposed method for the determination of OMG, MET and EZT in tablets

From: Analytical quality-by-design approach for development and validation of HPLC method for the simultaneous estimation of omarigliptin, metformin, and ezetimibe: application to human plasma and dosage forms

Drug

OMG

MET

EZT

Pharmaceutical preparation

Prepared Omaril® tablets (25 mg OMG/tab)

Glucophage® tablets (500 mg MET /tab)

Ezetimibe® tablets (10 mg EZT/tab)

 

Conc. taken

(µg/mL)

%Found a

Conc. taken

(µg/mL)

%Found a

Conc. taken

(µg/mL)

%Found a

 

0.20

99.75

0.5

101.06

0.10

99.6

0.25

98.56

1.0

98.41

0.20

96.80

0.30

100.87

2.5

102.26

0.30

97.33

0.40

99.78

5.0

98.06

0.40

99.63

0.50

99.36

10.0

101.34

0.50

102.92

1.0

99.64

15.0

98.46

1.0

100.71

1.5

101.77

20.0

101.21

1.5

99.91

2.0

99.15

25.0

99.62

2.0

99.80

Mean ± SD

 

99.86 ± 1.01

 

100.05 ± 1.62

 

99.59 ± 1.9

  1. a Mean of three separate determinations.