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Table 2 Analytical performance data for the proposed Method

From: Analytical quality-by-design approach for development and validation of HPLC method for the simultaneous estimation of omarigliptin, metformin, and ezetimibe: application to human plasma and dosage forms

Parameter

OMG

MET

EZT

Linearity range (µg/mL)

0.2-2.0

0.5–25.0

0.1-2.0

Limit of detection (LOD)a(µg/mL)

0.02

0.18

0.02

Limit of Quantitation (LOQ)b(µg/mL)

0.06

0.50

0.06

Regression equation

P = 0.43 C + 5 × 10− 5

P = 2.46 C – 0.23

P = 0.85 C + 0.11

Correlation coefficient (r)

0.9999

0.9999

0.9999

Standard deviation (S.D)

1.97

1.36

1.83

Percentage relative standard deviation (%RSD)

1.97

1.36

1.83

 S.D. of the residuals (Sy/x)

0.004

0.25

0.009

 S.D. of the intercept (Sa)

0.002

0.14

0.005

 S.D. of the slope (Sb)

0.002

0.01

0.005

  1. a LOD = 3.3 Sa/b, b LOQ = 10 Sa/b, where Sa = standard deviation of the intercept and b = slope.