Skip to main content

Table 4 Statistical comparison between the results obtained by the proposed methods and the pharmacopeial method for the analysis of ZNS

From: Green analytical chemistry and experimental design: a combined approach for the analysis of zonisamide

 

TLC

HPLC

Official method*

Mean

99.97

100.15

99.87

SD

1.22

0.52

0.81

Variance

1.50

0.27

0.65

N

5

6

7

Student’s t-test**

0.172

(2.23)

0.728

(2.20)

 

F value**

2.31

(4.53)

2.41

(4.95)

 
  1. *Official HPLC method using C18 column, acetonitrile: methanol: 1.36 g/L phosphate buffer (1:1:8 by volume) as a mobile phase and UV detection at 240 nm
  2. **Figures between parentheses represent the corresponding tabulated values of t and F at p = 0.05