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Table 3 Determination of ZNS in its pharmaceutical form and application of standard addition technique results using the proposed methods

From: Green analytical chemistry and experimental design: a combined approach for the analysis of zonisamide

Convagran® capsules

25 mg ZNS/capsule

B.N. M2012417

TLC

HPLC

Found*% ± SD

99.84 ± 0.25

100.64 ± 0.84

Standard addition technique

Taken*

Added*

Recovery%

4

2

101.76

99.98

4

100.88

98.93

6

100.73

99.68

Mean ± SD

101.12 ± 0.56

99.53 ± 0.54

Convagran® capsules

50 mg ZNS/capsule

B.N. M2013617

TLC

HPLC

Found*% ± SD

100.79 ± 0.88

99.51 ± 1.11

Standard addition technique

Taken*

Added*

Recovery%

4

2

100.24

99.67

4

100.20

98.97

6

100.94

100.40

Mean ± SD

100.46 ± 0.42

99.68 ± 0.72

Convagran® capsules

100 mg ZNS/capsule

B.N. M2000918

TLC

HPLC

Found*% ± SD

100.02 ± 1.36

99.69 ± 0.68

Standard addition technique

Taken*

Added*

Recovery%

4

2

100.72

98.52

4

100.76

100

6

100.63

100.69

Mean ± SD

100.71 ± 0.07

99.74 ± 1.11

  1. *Taken concentration for TLC = (4 µg/band), while added concentration = (2, 4, 6 µg/band) and for Taken concentration HPLC = (4 µg/mL), while added concentration = (2, 4, 6 µg/mL)