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Table 4 Comparative study between the proposed and reported methods for CAF, PSE, DOX and PAR in their pure forms

From: The simultaneous measurement of quaternary mixture in over-the-counter cold medications using sequential spectrophotometric resolution approach enhanced with in-lab sample enrichment

 

CAF

PSE

DOX

PAR

 

SSRT

*Official method [9]

SSRT

**Official method [62]

S,SRT

Reported method [34]

SSRT

Reported method [48]

Mean

100.26

100.02

100.19

100.33

100.03

99.74

100.31

99.98

SD

0.31

0.53

0.288

0.55

0.6

0.69

0.42

0.25

Variance

0.096

0.281

0.083

0.303

0.360

0.482

0.176

0.063

N

6

5

6

5

6

5

6

5

Student’s t-test (1.833)

0.893

 

0.514

 

0.757

 

1.612

 

F value (6.256)

2.923

 

3.647

 

1.323

 

0.354

 
  1. P = 0.05 Numbers between brackets are the tabulated ones
  2. *Official RP-HPLC method for determination of CAF using mobile phase, acetonitrile: sodium acetate buffer (45:55 v/v) pumped at a flow rate of 1.0 mL/min through the column (C18; 150.0 mm × 4.6 mm, 5.0 mm). **Official RP-HPLC method for determination of PSE using mobile phase, Methanol: Triethylamine phosphoric acid solution (pH 6.8) (10:90 v/v) pumped at a flow rate of 0.6 mL/min through the column (C18; 150.0 mm × 3 mm, 5.0 mm) at 30 _C. ***Direct UV spectrophotometric method, measuring the absorbance in water at 244 nm.
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