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Table 3 Assay results for determination of ASP, ATR and RAM drugs in pure forms by the proposed micellar HPLC method

From: Micellar eco-friendly HPLC method for simultaneous analysis of ternary combination of aspirin, atorvastatin and ramipril: application to content uniformity testing

Compound

Proposed method

Comparison method [9]

Amount taken, (µg/mL)

% Found

% Found

ASP

1

100.20

99.37

40

100.59

100.83

100

99.94

99.69

150

101.91

 

200

98.85

Mean ± SD

 

100.31 ± 1.11

99.69 ± 0.77

t-test

0.45 (2.45)

 

F- test

2.09 (19.25)

ATR

0.5

99.00

99.05

40

100.63

101.34

100

99.74

99.49

150

101.05

 

200

99.55

Mean ± SD

 

99.99 ± 0.83

99.96 ± 1.22

t-test

 

0.05 (2.45)

 

F-test

 

2.13 (6.95)

RAM

5

100.86

101.03

20

99.53

98.73

60

99.43

100.46

80

98.94

 

100

100.72

Mean ± SD

 

99.91 ± 0.85

100.07 ± 1.21

t-test

 

0.25 (2.45)

 

F-test

 

2.00 (6.95)