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Table 2 Analytical performance data for the determination of the ASP, ATR and RAM by the proposed Micellar HPLC method

From: Micellar eco-friendly HPLC method for simultaneous analysis of ternary combination of aspirin, atorvastatin and ramipril: application to content uniformity testing

Parameter

ASP

ATR

RAM

Range (µg/mL)

0.1–200

0.5–200

5.0-100

Intercept (a)

0.0077

0.0557

-0.1199

Slope (b)

0.0337

0.0498

0.0734

Correlation coefficient (r)

0.9998

0.9999

0.9999

 S.D. of residuals (Sy/x)

0.0027

0.00335

0.00148

 S.D. of intercept (Sa)

0.00005

0.00005

0.00007

 S.D. of slope (Sb)

0.00001

0.00002

0.00002

Regression equation

*P = 0.0337 C

+ 0.0077

*P = 0.0498 C

+ 0.0557

*P = 0.0734 C − 0.1199

Percentage relative standard deviation, % RSD

1.315

1.027

1.078

Percentage relative error, % Error

0.412

0.309

0.407

Limit of detection, LOD (µg/mL)

0.19

0.13

0.30

Limit of quantitation, LOQ (µg/mL)

0.63

0.44

0.99

  1. *P is the peak area ratio, C is the concentration of the drug in µg/mL and r is the correlation coefficient