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Table 3 Predicted probability of toxicity profile of nirmatrelvir and its degradation products (DP-1–DP-6)

From: Green adherent degradation kinetics study of Nirmatrelvir, an oral anti-COVID-19: characterization of degradation products using LC–MS with insilico toxicity profile

Classification

Target

shorthand

Drug

DP-1

DP-2

DP-3

DP-4

DP-5

DP-6

Probability of being inactive

LD 50 (mg/kg)

3000

3000

3000

3000

3000

5000

826

 

Toxicity Class

5

5

5

5

5

5

4

 

Hepatotoxicity

Hepatotoxicity

dili

NA

NA

NA

NA

NA

NA

NA

0.87

Carcinogenicity

Carcinogenicity

carcino

NA

NA

NA

NA

NA

NA

NA

0.60

Immunotoxicity

Immunotoxicity

immuno

NA

NA

NA

NA

NA

NA

NA

0.63

Mutagenicity

Mutagenicity

Mutagen

NA

NA

NA

NA

NA

NA

NA

0.57

Cytotoxicity

Cytotoxicity

Cyto

NA

NA

NA

NA

NA

NA

NA

0.67