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Table 2 Pseudo first-order rate constants (K) and half-lives (t1/2) for the alkaline and acidic hydrolysis of NMV using different temperatures

From: Green adherent degradation kinetics study of Nirmatrelvir, an oral anti-COVID-19: characterization of degradation products using LC–MS with insilico toxicity profile

Alkaline hydrolysis (0.1 M NaOH)

Temperature/Strength

K (h −1)

t1/2 (h)

70 ℃

2.46

0.28

60 ℃

1.95

0.35

50 ℃

1.33

0.52

Room temperature (25 ˚C) a

1.22

0.56

Acidic hydrolysis (2 M HCl)

Temperature/Strength

K (h −1)

t1/2 (h)

80 ℃

0.89

0.78

70 ℃

0.62

1.11

60 ℃

0.40

1.72

Room temperature (25 ˚C)a

0.13

5.39

  1. aCalculated by extrapolation of the Arrhenius plot