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Table 1 Summary of the degradation behaviour of NMV using the proposed HPLC–DAD method

From: Green adherent degradation kinetics study of Nirmatrelvir, an oral anti-COVID-19: characterization of degradation products using LC–MS with insilico toxicity profile

  

Degradation Conditions

% Recovery

Alkaline degradation

Mild

0.1 M NaOH, 60 °C, ½ h

39.56

Acidic degradation

Mild

0.1 M HCl, RT, 24 h

98.85

Strong

1 M HCl, 90 °C, 1 h

66.26

Neutral degradation

Mild

H2O, 60 °C, ½ h

100.21

Strong

H2O, 80 °C, 1 h

100.24

Oxidative degradation

Mild

10% H2O2, RT, 24 h

99.65

Strong

25% H2O2, 60 °C, ½ h

101.01

Sun light degradation

 

Direct sun light for 4 h

98.96

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BMC Chemistry

ISSN: 2661-801X

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