Parameters | EMP | LIN | MET |
---|
Reported method a [23] | Current method | Reported method a [23] | Current method | Reported method a [23] | Current method |
---|
Mean | 99.65 | 101.20 | 99.65 | 99.08 | 99.96 | 99.59 |
SD | 0.388 | 0.355 | 0.357 | 1.272 | 0.250 | 0.671 |
Variance | 0.151 | 0.126 | 0.127 | 1.618 | 0.063 | 0.450 |
t-testb | --- | 0.20 (2.78) | --- | 1.43 (2.78) | --- | 1.12 (2.78) |
F-testb | --- | 1.19 (19.00) | --- | 12.70 (19.00) | --- | 7.20 (19.00) |
- a Reversed phase HPLC-DAD employing Agilent C18 column (4.6 × 250 mm, 5 μm p.s.) and a mobile phase composed of methanol and 0.01 M sodium di-hydrogen orthophosphate buffer of pH 2.55 (adjusted with ortho-phosphoric acid) eluted in a gradient mode with detection at 218 and 224 nm.
- b The theoretical values of t and F at P = 0.05 are (2.78) and (19.00), respectively where n = 3.
- EMP, empagliflzin; LIN, linagliptin; MET, metformin.