Pharmaceutical preparation | Current HPLC method | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
EMP | LIN | MET | ||||||||||
Trijardy ® tablets, (25 mg EMP/5 mg LIN/1000 mg MET per tablet) | Mean ± SD | 101.20 ± 0.355 | 99.08 ± 1.272 | 99.59 ± 0.671 | ||||||||
Standard addition technique | ||||||||||||
Current HPLC method | ||||||||||||
Pharmaceutical formulation taken ( µg/mL) | Pure drug added (µg/mL) | % Recovery a of EMP | % Recovery a of LIN | % Recovery a of MET | ||||||||
EMP | LIN | MET | EMP | LIN | MET | |||||||
2.5 | 0.5 | 100 | 2.00 | 0.40 | 80.00 | 101.02 | 99.82 | 99.72 | ||||
2.50 | 0.50 | 100.00 | 100.47 | 101.61 | 101.11 | |||||||
3.00 | 0.60 | 120.00 | 99.76 | 100.52 | 101.58 | |||||||
Mean ± SD | 100.42 ± 0.630 | 99.08 ± 1.272 | 99.59 ± 0.671 |