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Table 1 Greenness assessment of the two proposed separation methods by analytical eco-scale, NEMI, GAPI and AGREE tools

From: An eco-friendly separation-based framework for quantitative determination and purity testing of an antihypertensive ternary pharmaceutical formulation

For HPTLC-densitometric method

Eco-scale assessment

NEMI pictogram

GAPI assessment

AGREE assessment

Reagents

Penalty points (PPs)

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 Ammonia (25%)

6

 Water

0

 Ethanol

4

 Ethyl acetate

4

Instrument

 

 Energy consumption

1

 Occupational hazard

3

 Waste

6

Total PPs

24

Analytical eco-scale total score

76

Comment

Excellent green analysis

For CZE-DAD method

Eco-scale assessment

NEMI pictogram

GAPI assessment

AGREE assessment

Reagents

Penalty points (PPs)

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 Sodium tetraborate decahydrate

4

 Water

0

Instrument

 

 Energy consumption

2

 Occupational hazard

0

 Waste

4

Total PPs

10

Analytical eco-scale total score

90

Comment

Excellent green analysis