Table 7 Accuracy of the proposed HPLC method using mobile phase n-hexane: ethanol: 0.1% DEA (75: 25: 0.1 by volume) for quantitative determination of carvedilol and atenolol enantiomers
Carvedilol | Atenolol | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Taken \(\mathrm{\mu g}/\mathrm{mL}\) | Found \(\mathrm{\mu g}/\mathrm{mL}\) enant.1 | Recovery % enant.1 | Found \(\mathrm{\mu g}/\mathrm{mL}\) enant.2 | Recovery % enant.2 | Taken \(\mathrm{\mu g}/\mathrm{mL}\) | Found \(\mathrm{\mu g}/\mathrm{mL}\) enant.1 | Recovery % enant.1 | Found \(\mathrm{\mu g}/\mathrm{mL}\) enant.2 | Recovery % enant.2 |
20.00 | 19.92 | 99.60 | 19.86 | 99.30 | 50.00 | 50.09 | 100.18 | 50.40 | 100.80 |
40.00 | 40.77 | 101.93 | 39.99 | 99.98 | 100.00 | 101.69 | 101.69 | 101.96 | 101.96 |
60.00 | 59.32 | 98.87 | 60.15 | 100.25 | 150.00 | 150.56 | 100.37 | 147.22 | 98.15 |
72.00 | 72.43 | 100.60 | 71.44 | 99.22 | 180.00 | 179.34 | 99.63 | 177.50 | 98.61 |
80.00 | 80.96 | 101.20 | 81.58 | 101.98 | 200.00 | 202.50 | 101.25 | 202.28 | 101.14 |
88.00 | 87.38 | 99.30 | 87.16 | 99.05 | 220.00 | 218.22 | 99.19 | 218.80 | 99.45 |
100.00 | 100.52 | 100.52 | 99.81 | 99.81 | 250.00 | 249.31 | 99.72 | 251.83 | 100.73 |
Mean | 100.29 | 99.94 | 100.29 | 100.12 | |||||
R.S.D | 1.088 | 1.000 | 0.898 | 1.405 | |||||