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Table 2 System suitability parameters of the proposed HPLC method for quantitative determination of metoprolol, nebivolol carvedilol and atenolol enantiomers using mobile phase n-hexane: ethanol: DEA (75: 25: 0.1 by volume)

From: Enantioseparation, quantification, molecular docking and molecular dynamics study of five β-adrenergic blockers on Lux-Cellulose-2 column

Parameter

Metoprolol

Nebivolol

Carvedilol

Atenolol

Enant. 1

Enant.2

Enant. 1

Enant.2

Enant. 1

Enant.2

Enant. 1

Enant.2

Retention time (Rt) (min)

5.23

5.66

6.17

7.47

12.52

16.64

30.14

46.13

Selectivity (\(\propto \))

1.45

1.09

1.08

1.21

1.70

1.34

1.80

1.54

Resolution (Rs)

1.94

1.94

3.35

3.35

4.57

4.57

8.08

8.08

Tailing factor

0.62

0.64

0.51

0.55

0.50

0.57

0.68

0.65

Number of theoretical plates (N)

9082

8888

5104

5176

4044

4456

5948

5430

Height equivalent to theoretical plates (mm)

78.41

73.31

16.28

14.06

29.82

23.97

14.35

7.92