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Table 1 System suitability parameters of the proposed HPLC method for quantitative determination of bisoprolol, carvedilol and atenolol enantiomers using mobile phase n-hexane: ethanol: DEA (60: 40: 0.1 by volume)

From: Enantioseparation, quantification, molecular docking and molecular dynamics study of five β-adrenergic blockers on Lux-Cellulose-2 column

Parameter

Bisoprolol

Carvedilol

Atenolol

Enant. 1

Enant.2

Enant.1

Enant.2

Enant.1

Enant.2

Retention time (Rt)(min)

4.33

4.74

6.92

8.70

13.71

20.31

Selectivity (\(\propto \))

1.23

1.10

1.46

1.26

1.57

1.47

Resolution (Rs)

2.17

2.17

3.73

3.73

7.04

7.04

Number of theoretical plates (N)

7531

7595

3924

4088

5221

5042

Height equivalent to theoretical plates (mm)

121.76

106.58

64.71

53.31

35.55

23.93