Table 6 Robustness study of the proposed RP-HPLC method using Box-Behnken experimental design
Parameter | Drugs | Â | Normal value | pH of buffer | % of Acetonitrile | Flow rate | ||
|---|---|---|---|---|---|---|---|---|
6.15 | 5.75 | 77 | 1.6 | 1.2 | ||||
R1 | MTL/IND | Eq-1 | 8.11 | 7.5 | 8.41 | 8.33 | 7.40 | 8.83 |
Experimental value | 7.98 | 6.66 | 8.13 | 7.72 | 7.61 | 8.25 | ||
R2 | IND/BET | Eq-2 | 7.05 | 8.82 | 5.94 | 8.08 | 6.96 | 7.14 |
Experimental value | 7.64 | 9.52 | 6.00 | 8.39 | 6.96 | 7.68 | ||