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Table 3 Statistical comparison between the results obtained by applying the proposed spectrophotometric methods and reported method for determination of DPA

From: Comparative study of extension area based methods for spectrophotometric determination of desmopressin acetate in the presence of its acid-induced degradation products

Parameters

First derivative

Ratio derivative

Ratio difference

Mean centering

Dual wavelength

Reported method [6]***

Mean

100.21

99.94

100.11

99.78

99.47

98.99

S.D

1.143

0.999

1.036

0.607

1.082

0.409

N*

5

5

5

5

5

5

t-test**

2.203 (2.365)

1.931 (2.365)

2.199 (2.365)

2.319 (2.365)

0.907 (2.365)

–

F-value**

7.820 (9.117)

5.984 (9.117)

6.426 (9.117)

2.206 (9.117)

7.014 (9.117)

–

  1. *Number of experimental.
  2. **The values in the parenthesis are the corresponding theoretical values of t and F at (P = 0.05).
  3. ***Determination of the Content of Desmopressin in Pharmaceutical Preparations by HPLC and Validation of the Method [6].
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BMC Chemistry

ISSN: 2661-801X

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