Validated HPLC–PDA methodology utilized for simultaneous determination of Etoricoxib and Paracetamol in the presence of Paracetamol toxic impurities

Table 2 Parameters required for the proposed HPLC method's system suitability testing

Parameters	PAP	PCM	PHA	ETO	Reference value (50)
Resolution (R_s)^a	12.290	14.498		20.296	R_s > 2
Selectivity factor (α)^b	2.372	1.545		1.504	α > 1
Capacity factor (K)	2.456	5.827	7.005	8.549	1 < K < 10
Number of theoretical plates (N)	2437	9838	19595	41923	N > 2000
Tailing factor (T)	1.550	1.352	1.352	1.280	T ≤ 2

^a Resolution (R_s) = 2(t_RB—t_RA) / (W_B+W_A), where t_R is the retention time and w is the peak width calculated for each of the two successive peaks
^b Selectivity (α) = k’₂/k’₁ calculated for each of two successive peaks

ISSN: 2661-801X