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Table 1 Gradient program of the RP-HPLC method for separation of the studied components

From: Validated HPLC–PDA methodology utilized for simultaneous determination of Etoricoxib and Paracetamol in the presence of Paracetamol toxic impurities

Time, min

Phosphate buffer, %

Acetonitrile, %

0 a

93

7

0–2.5

75

25

2.5–5

50

50

5–7.5

25

75

7.5–9.5

93

7

  1. a gradient profile starting with 93: 7 (Phosphate buffer: Acetonitrile)