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Table 1 Antimalarial activity test for the synthesized compounds at a dose of 48.46 µmol/kg

From: Synthesis, antimalarial, antileishmanial evaluation, and molecular docking study of some 3-aryl-2-styryl substituted-4(3H)-quinazolinone derivatives

Test compounds

Structure*

Dose (mg/kg)

% Parasitemia

% Suppression

Mean survival time (day)

6

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17.95

39.22 ± 0.7

38.89

6.5 ± 0.3

7

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18.07

35.69 ± 0.69

45.3

6.9 ± 0.5

8

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19.21

19.57 ± 0.77

70.01

9.4 ± 0.37

10

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20.67

16.85 ± 0.39

74.18

9.8 ± 0.24

11

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17.17

25.27 ± 0.76

61.27

7.3 ± 0.54

12

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17.17

32 ± 0.5

50.96

7.6 ± 1.12

13

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18.63

24.13 ± 0.29

63.02

7.9 ± 0.3

NC**

–

1 mL/100 g

65.25 ± 0.73

0.0

5.8 ± 0.17

CQ

–

25

0

100

ND

  1. *The equimolar concentration of the synthesized compounds as compared to the reference drug, CQ
  2. **Values are mean ± standard deviations, p ˂ 0.05
  3. NC negative control, CQ chloroquine sulfate, ND, no mice death was recorded during the study period