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Table 3 Optimization of adapted synthesis as depicted in Scheme 2

From: A green and efficient synthetic methodology towards the synthesis of 1-allyl-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives

Entry

Solvent

Triethylamine ratio

Ethylchloroformate ratio

4-Cl-aniline Ratio

% Yield

1

DMF

1.5

1.2

1.2

51

2

DMF

2

1.5

1.5

78

3

DMF

2.5

2

2

90

4

DMSO

2.5

2

2

87

  1. Note: DMF was selected for further synthesis due to the ease of final aqueous extraction