Table 1 Anti-oxidant activity (µmol/ml) of synthesized (E)-2-(3-(substitutedstyryl)-5-(substitutedphenyl)-4,5-dihydropyrazol-1-yl)benzo[d]thiazole derivatives (VI)
Comp | Conc | %Inhibition ± SEM | IC50 | Comp | Conc | %Inhibition ± SEM | IC50 |
|---|---|---|---|---|---|---|---|
Z1 | 500 250 125 62.5 31.25 | 85.54 ± 0.22** 76.10 ± 0.04** 62.54 ± 0.29** 49.84 ± 0.05** 35.33 ± 0.13** | 0.13 | Z11 | 500 250 125 62.5 31.25 | 51.75 ± 0.12** 40.67 ± 0.04** 31.30 ± 0.05** 29.17 ± 0.02** 24.56 ± 0.03** | 4.8 |
Z2 | 500 250 125 62.5 31.25 | 96.89 ± 0.02 ** 71.08 ± 0.02** 50.46 ± 0.29** 30.57 ± 0.03** 21.72 ± 0.02** | 0.71 | Z12 | 500 250 125 62.5 31.25 | 86.50 ± 0.21** 62.82 ± 0.09** 48.05 ± 0.01** 40.12 ± 0.03** 36.96 ± 0.02** | 1.68 |
Z3 | 500 250 125 62.5 31.25 | 72.67 ± 0.22** 52.30 ± 0.00** 37.38 ± 0.02** 29.39 ± 0.01** 23.70 ± 0.07** | 2.03 | Z13 | 500 250 125 62.5 31.25 | 56.07 ± 0.02** 48.56 ± 0.02** 36.70 ± 0.04** 29.54 ± 0.09** 24.50 ± 0.01** | 0.44 |
Z4 | 500 250 125 62.5 31.25 | 68.26 ± 0.07** 53.70 ± 0.09** 39.35 ± 0.06** 28.11 ± 1.05** 22.01 ± 0.00** | 0.61 | Z14 | 500 250 125 62.5 31.25 | 53.00 ± 0.94** 39.13 ± 0.34** 29.63 ± 0.00** 22.58 ± 0.00** 18.54 ± 0.01** | 5.41 |
Z5 | 500 250 125 62.5 31.25 | 70.82 ± 0.4** 57.59 ± 0.07** 45.80 ± 0.04** 39.61 ± 0.30** 34.40 ± 0.18** | 1.05 | Z15 | 500 250 125 62.5 31.25 | 55.37 ± 0.11** 43.49 ± 0.13** 32.89 ± 0.03** 28.20 ± 0.04** 24.37 ± 0.00** | 0.86 |
Z6 | 500 250 125 62.5 31.25 | 28.96 ± 0.03** 25.85 ± 0.03** 22.16 ± 0.00** 19.99 ± 0.00** 17.53 ± 0.02** | 0.74 | Z16 | 500 250 125 62.5 31.25 | 68.22 ± 0.00** 54.48 ± 0.01** 43.37 ± 0.00** 37.93 ± 0.00** 32.39 ± 0.01** | 8.43 |
Z7 | 500 250 125 62.5 31.25 | 86.39 ± 0.04** 65.10 ± 0.00** 50.44 ± 0.00** 30.83 ± 0.01** 23.81 ± 0.02** | 0.71 | Z17 | 500 250 125 62.5 31.25 | 39.80 ± 0.33** 34.61 ± 0.18** 26.75 ± 0.04** 23.96 ± 0.03** 18.91 ± 0.04** | 0.54 |
Z8 | 500 250 125 62.5 31.25 | 83.87 ± 0.01** 64.66 ± 0.07** 27.30 ± 0.02** 21.53 ± 0.00** 19.83 ± 0.16** | 0.50 | Z18 | 500 250 125 62.5 31.25 | 86.11 ± 0.3** 49.05 ± 0.00** 31.67 ± 0.05** 26.63 ± 0.01** 23.13 ± 0.01** | 1.75 |
Z9 | 500 250 125 62.5 31.25 | 64.36 ± 0.03** 49.79 ± 0.00** 34.62 ± 0.01** 23.35 ± 0.00** 12.81 ± 0.02** | 0.70 | Z19 | 500 250 125 62.5 31.25 | 50.57 ± 0.1** 38.53 ± 0.31** 28.53 ± 0.07** 22.92 ± 0.00** 21.84 ± 0.04** | 0.58 |
Z10 | 500 250 125 62.5 31.25 | 61.12 ± 0.06** 47.88 ± 0.00** 36.72 ± 0.00** 26.70 ± 0.03** 20.95 ± 0.01** | 0.87 | Z20 | 500 250 125 62.5 31.25 | 52.64 ± 0.01** 42.45 ± 0.01** 32.53 ± 0.01** 26.87 ± 0.01** 21.62 ± 0.04** | 0.88 |
|  | STD | 500 250 125 62.5 31.25 | 99.921 ± 0.03 88.951 ± 0.00 74.337 ± 0.24 55.319 ± 0.30 40.186 ± 0.51 | 0.50 | |||