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Table 2 Optimization of reaction conditions of conversion of 4-chlorobenzaldehyde oxime to 4-chlorobenzonitrilea

From: Organoselenium functionalized SBA-15 as a new catalyst for the cyanide-free conversion of oximes to nitriles

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Entry

Cat./g

Temp. (°C)

H2O2 (30%) mmol

Time (h)

Solvent

Yield (%)

1

None

65

2.45

10

Acetonitrile

Trace

2

0.01

65

2.45

10

Acetonitrile

78%

3

0.02

65

2.45

10

Acetonitrile

95%

4

0.03

65

2.45

10

Acetonitrile

95%

6

0.02

65

2.45

10

Water

Trace

7

0.02

65

2.45

10

EtOH

55

8

0.02

65

2.45

10

MeOH

55

9

0.02

65

2.45

10

Toluene

Trace

10

0.02

65

2.45

10

CHCl3

Trace

11

0.02

65

1.2

10

Acetonitrile

72

12

0.02

65

3.6

10

Acetonitrile

95

13

0.02

75

2.45

10

Acetonitrile

83

  1. Bold values indicate the optimum condition
  2. aReaction condition: aldoxime (1 mmol), solvent 3 mL under airflow
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BMC Chemistry

ISSN: 2661-801X

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