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Table 2 In vitro cytotoxic activity of the quinazoline derivatives

From: Synthesis, biological evaluation, and computational studies of some novel quinazoline derivatives as anticancer agents

Compound

Cytotoxicity (IC50 ± SD) µM

MCF-7

A549

5637

MRC-5

7a

337.5 ± 9.6

190.2 ± 5.3

290.4 ± 7.6

 > 500

7b

82.1 ± 5.6

67.3 ± 6.5

51.4 ± 2.5

201.9 ± 2.3

7c

232.8 ± 11.8

347.6 ± 25.3

139.8 ± 5.3

 > 500

7d

266.5 ± 21.7

178.2 ± 2.9

83.5 ± 4.9

 > 500

7e

99.7 ± 4

113.2 ± 4.56

103.0 ± 2.1

339.0 ± 2.7

7f

90.2 ± 7.1

227.5 ± 3.9

74.8 ± 2.4

 > 500

7g

241.3 ± 46.3

292.3 ± 46.3

233.4 ± 39.4

 > 500

7h

445.39 ± 42.0

175.2 ± 28.5

235.6 ± 1.0

 > 500

Cisplatin

36.5 ± 1.9

14.8 ± 0.27

37.7 ± 1.9

45.2 ± 2.5