Fig. 11

Graphical Abstract; Polycaprolactone (PCL)-based nanocapsules loaded with the antitumor agent doxorubicin (Dox) were prepared using the double emulsion technique. The promising nanocarriers (212 nm) were defined to have a narrow monodispersed unimodal size distribution with ZP of -22.3 mv, PDI of 0.019, and DL capacity of 16.88 %. The safety of the little cargo was ensured by having an enhanced drug release rate reaching 98 % at the cancer acidic medium (pH 4.8) compared to only 26 % at the physiological medium (pH 7.4), meaning less drug exposure to normal cells. Moreover, nanoencapsulation has effectively reduced Dox-cytotoxicity on normal Vero cells, while notably increasing the drug sensitivity of cancer HepG2 cells