From: Design, synthesis and evaluation of novel 1,2,4-triazole derivatives as promising anticancer agents
Compound | X1 | X2 | X3 | Y | R | IC50 (μM ± SEM) |  | ||
---|---|---|---|---|---|---|---|---|---|
 | MCF-7 | Hela | A549 | MRC-5 | |||||
7a | H | H | – | C = O | H | 154.2 ± 5.8 | 92.4 ± 7.3 | 149.6 ± 5.3 |  > 300 |
7b | Cl | Cl | – | C = O | H | 23.4 ± 2.6 | 7.9 ± 3.1 | 75.8 ± 4.6 | 72.6 ± 3.4 |
7c | Cl | H | – | C = O | C6H5 | 60.0 ± 4.9 | 81.7 ± 6.3 | 177.3 ± 5.9 | 201.2 ± 9.5 |
7d | Br | H | – | C = O | C6H5 | 9.8 ± 0.9 | 12.1 ± 3.6 | 43.4 ± 4.5 | 35.6 ± 2.7 |
7e | Cl | Cl | – | C = O | C6H5 | 4.7 ± 1.4 | 2.9 ± 1.1 | 9.4 ± 1.8 | 27.8 ± 3.7 |
8a | H | H | – | CH2 | H | 158.3 ± 3.5 | 141.5 ± 2.1 | 127.3 ± 4.9 | 279.1 ± 2.5 |
8b | Cl | H | – | CH2 | C6H5 | 178.5 ± 2.5 | 198.3 ± 5.5 | 124.1 ± 3.4 | 279.1 ± 2.8 |
8c | Br | H | – | CH2 | C6H5 | 52.8 ± 7.4 | 79.1 ± 2.5 | 104.5 ± 7.3 | 104.5 ± 7.3 |
10a | H | H | H | – | H | 6.4 ± 1.7 | 5.6 ± 2.8 | 21.1 ± 4.2 | 21.7 ± 1.5 |
10b | Cl | H | H | – | H | 62.6 ± 2.5 | 48.3 ± 4.1 | 110.5 ± 1.3 | 259.3 ± 8.3 |
10c | Br | H | H | – | H | 17.3 ± 5.4 | 32.4 ± 6.9 | 103.7 ± 1.3 | 57.8 ± 1.7 |
10d | Br | H | Cl | – | H | 10.2 ± 2.1 | 9.8 ± 1.7 | 16.5 ± 2.6 | 42.8 ± 2.1 |
10e | Cl | Cl | H | – | H | 45.4 ± 6.5 | 31.6 ± 4.2 | 103.7 ± 5.9 | 104.5 ± 7.3 |
10f | H | H | H | – | C6H5 | 134.5 ± 4.5 | 82.7 ± 5.8 | 114.5 ± 7.6 | 289.1 ± 10.2 |
10 g | F | H | H | – | C6H5 | 93.0 ± 3.1 | 127.9 ± 6.1 | 149.8 ± 4.9 | 257.2 ± 4.3 |
10 h | Cl | H | H | – | C6H5 | 89.0 ± 5.2 | 172.3 ± 7.1 | 112.5 ± 10.8 | 249.3 ± 5.8 |
10i | Br | H | H | – | C6H5 | 72.2 ± 6.5 | 59.3 ± 2.7 | 134.8 ± 5.3 | 218 ± 3.2 |
10 J | F | F | H | – | C6H5 | 45.4 ± 3.2 | 12.3 ± 1.9 | 100.7 ± 1.8 | 101.2 ± 1.3 |
10 k | Cl | Cl | H | – | C6H5 | 44.1 ± 7.6 | 121.2 ± 6.8 | 102.5 ± 5.2 | 147.9 ± 6.1 |
Cis platin | – | – | – | – | – | 36.5 ± 1.9 | 12.3 ± 3.3 | 14.8 ± 0.27 | 45.2 ± 2.5 |