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Table 1 Cytotoxicity of the synthesized compounds against MCF-7, Hela and A549 cell lines [IC50 (μM)]

From: Design, synthesis and evaluation of novel 1,2,4-triazole derivatives as promising anticancer agents

Compound

X1

X2

X3

Y

R

IC50 (μM ± SEM)

 
 

MCF-7

Hela

A549

MRC-5

7a

H

H

–

C = O

H

154.2 ± 5.8

92.4 ± 7.3

149.6 ± 5.3

 > 300

7b

Cl

Cl

–

C = O

H

23.4 ± 2.6

7.9 ± 3.1

75.8 ± 4.6

72.6 ± 3.4

7c

Cl

H

–

C = O

C6H5

60.0 ± 4.9

81.7 ± 6.3

177.3 ± 5.9

201.2 ± 9.5

7d

Br

H

–

C = O

C6H5

9.8 ± 0.9

12.1 ± 3.6

43.4 ± 4.5

35.6 ± 2.7

7e

Cl

Cl

–

C = O

C6H5

4.7 ± 1.4

2.9 ± 1.1

9.4 ± 1.8

27.8 ± 3.7

8a

H

H

–

CH2

H

158.3 ± 3.5

141.5 ± 2.1

127.3 ± 4.9

279.1 ± 2.5

8b

Cl

H

–

CH2

C6H5

178.5 ± 2.5

198.3 ± 5.5

124.1 ± 3.4

279.1 ± 2.8

8c

Br

H

–

CH2

C6H5

52.8 ± 7.4

79.1 ± 2.5

104.5 ± 7.3

104.5 ± 7.3

10a

H

H

H

–

H

6.4 ± 1.7

5.6 ± 2.8

21.1 ± 4.2

21.7 ± 1.5

10b

Cl

H

H

–

H

62.6 ± 2.5

48.3 ± 4.1

110.5 ± 1.3

259.3 ± 8.3

10c

Br

H

H

–

H

17.3 ± 5.4

32.4 ± 6.9

103.7 ± 1.3

57.8 ± 1.7

10d

Br

H

Cl

–

H

10.2 ± 2.1

9.8 ± 1.7

16.5 ± 2.6

42.8 ± 2.1

10e

Cl

Cl

H

–

H

45.4 ± 6.5

31.6 ± 4.2

103.7 ± 5.9

104.5 ± 7.3

10f

H

H

H

–

C6H5

134.5 ± 4.5

82.7 ± 5.8

114.5 ± 7.6

289.1 ± 10.2

10 g

F

H

H

–

C6H5

93.0 ± 3.1

127.9 ± 6.1

149.8 ± 4.9

257.2 ± 4.3

10 h

Cl

H

H

–

C6H5

89.0 ± 5.2

172.3 ± 7.1

112.5 ± 10.8

249.3 ± 5.8

10i

Br

H

H

–

C6H5

72.2 ± 6.5

59.3 ± 2.7

134.8 ± 5.3

218 ± 3.2

10 J

F

F

H

–

C6H5

45.4 ± 3.2

12.3 ± 1.9

100.7 ± 1.8

101.2 ± 1.3

10 k

Cl

Cl

H

–

C6H5

44.1 ± 7.6

121.2 ± 6.8

102.5 ± 5.2

147.9 ± 6.1

Cis platin

–

–

–

–

–

36.5 ± 1.9

12.3 ± 3.3

14.8 ± 0.27

45.2 ± 2.5